Induction of cemip in chondrocytes by inflammatory cytokines: Underlying mechanisms and potential involvement in osteoarthritis

Research output: Contribution to journalArticle

Abstract

In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1β (IL-1β) stimulation in chondrocytic cells. We also observed that ERK activation and NF-κB nuclear translocation were involved in the induction of CEMIP by IL-1β. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1β-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.

Original languageEnglish
Article number3140
JournalInternational journal of molecular sciences
Volume21
Issue number9
DOIs
Publication statusPublished - May 1 2020

Keywords

  • Cell migration-inducing hyaluronidase 1 (CEMIP)
  • Chondrocyte
  • Hyaluronan
  • Mechanical strain
  • Nuclear factor kappa B (NF-κB)
  • Osteoarthritis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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