Induction Concurrent Chemoradiation Therapy for Invading Apical Non-Small Cell Lung Cancer

Shinichiro Miyoshi, Keiji Iuchi, Kenji Nakamura, Katsuhiro Nakagawa, Hajime Maeda, Kiyoshi Ohno, Kazuya Nakahara, Noboru Nakano, Meinoshin Okumura, Mitsunori Ohta

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12 Citations (Scopus)

Abstract

Objective: Although non-small cell lung cancer (NSCLC) involving the superior sulcus has been generally treated with radiation therapy (RT) followed by surgery, local recurrence is still a big problem to be solved. We investigated a role of induction therapy, especially induction concurrent chemoradiation therapy (CRT), on the surgical results of this type of NSCLC. Method: We retrospectively reviewed 30 patients with NSCLC invading the apex of the chest wall who underwent surgery from 1987 to 1996. Ten patients (57±8 years) received surgery alone, 9 (55±13 years) received RT (42±7 Gy) followed by surgery and 11 (51±9 years) received cisplatin based chemotherapy and RT (47±5 Gy) as an induction therapy. Results: Two and 4-year survival rates were 30% and 20% in patients with surgery alone, 22% and 11% in patients with induction RT, and 73% and 53% in patients with induction CRT, respectively. The survival was significantly better in patients with induction CRT than those with induction RT or surgery alone. Univariate analysis demonstrated that curability (yes versus no: p=0.027) and induction therapy (surgery alone and RT versus CRT: p=0.0173) were significant prognostic factors. Multivariate analysis revealed that only induction therapy (p=0.0238) was a significant prognostic factor. Conclusions: Induction CRT seems to improve the survival in patients with NSCLC invading the apex of the chest wall compared with induction RT or surgery alone.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalJapanese Journal of Thoracic and Cardiovascular Surgery
Volume52
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Chemotherapy
  • Lung cancer surgery
  • Pancoast tumor
  • Radiation therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Miyoshi, S., Iuchi, K., Nakamura, K., Nakagawa, K., Maeda, H., Ohno, K., Nakahara, K., Nakano, N., Okumura, M., & Ohta, M. (2004). Induction Concurrent Chemoradiation Therapy for Invading Apical Non-Small Cell Lung Cancer. Japanese Journal of Thoracic and Cardiovascular Surgery, 52(3), 120-126. https://doi.org/10.1007/s11748-004-0127-7