Induction Chemotherapy followed by Hyperfractionated Radiotherapy with Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer

Kumiko Karasawa, Hirofumi Shinoda, Kuniaki Katsui, Kaori Seki, Mari Kohno, Nahoko Hanyu, Sachiko Nasu, Hiroyuki Muramatsu, Katsuya Maebayashi, Norio Mitsuhashi, Toshio Yoshihara

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Abstract

Background: The aim of this study was to improve tumor control, the survival rate and organ preservation for locally advanced head and neck cancer by using induction chemotherapy followed by hyperfractionated radiotherapy and concurrent chemotherapy. Materials and Methods: Thirty-five patients with stage III-IVB head and neck cancer were treated with this protocol, Induction chemotherapy consisted of cisplatin and fluorouracil and concurrent chemotherapy consisted of carboplatin and doxifluridin. Radiotherapy was administered twice a day until a dose of 72 Gy was reached. Results: Twenty-two (63%) and 13 patients (37%) achieved complete responses and partial responses, respectively. In terms of non-hematological toxicities, grade 3 mucositis was observed in 49 % of the patients. The overall 5-year survival was 53.5 % and the progression-free survival was 40.6 %. Conclusion: Response to induction chemotherapy was useful as a predictive factor for ultimate outcome and organ conservation. More intensive regimen or other combination chemotherapy is needed to improve treatment outcome with hyperfractionated radiotherapy.

Original languageEnglish
Pages (from-to)5031-5036
Number of pages6
JournalAnticancer research
Volume23
Issue number6 D
Publication statusPublished - Nov 1 2003

Keywords

  • Chemoradiotherapy
  • Concurrent chemotherapy
  • Head and neck cancer
  • Hyperfractionated radiotherapy
  • Induction chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Karasawa, K., Shinoda, H., Katsui, K., Seki, K., Kohno, M., Hanyu, N., Nasu, S., Muramatsu, H., Maebayashi, K., Mitsuhashi, N., & Yoshihara, T. (2003). Induction Chemotherapy followed by Hyperfractionated Radiotherapy with Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer. Anticancer research, 23(6 D), 5031-5036.