Induction Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer

Akihiro Miura, Junichi Sou, Kazuhiko Shien, Hiromasa Yamamoto, Shinichi Toyooka

Research output: Contribution to journalArticle

Abstract

The management of locally advanced non-small cell lung cancer (LA-NSCLC) is still controversial, because of complicated patient status and poor prognosis. The purpose of this study was to evaluate the treatment results for induction chemoradiotherapy (iCRT) followed by surgery for LA-NSCLC. From 1999 to 2016, 157 patients were surgically treated after iCRT in our hospital, and their median follow-up was 43 months. Overall survival( OS) was 66.8%, and relapse-free survival( RFS) was 52.0%. The poor prognostic factor in OS by multivariate analysis was lower-lobe origin, incomplete radiotherapy, reoperation, and RFS was lower-lobe origin. The result of our hospital was feasible compared with definitive CRT. The definitive CRT is mainstream for treatment of LA-NSCLC and adjuvant anti-programmed death ligand 1 antibody will influence the treatment strategy, however there are some patients who can get benefit only by iCRT followed by surgery. iCRT followed by surgery is one of the feasible treatment for LA-NSCLC.

Original languageEnglish
Pages (from-to)270-277
Number of pages8
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume71
Issue number4
Publication statusPublished - Apr 1 2018

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Chemoradiotherapy
Non-Small Cell Lung Carcinoma
Survival
Recurrence
Therapeutics
Survival Analysis
Reoperation
Radiotherapy
Multivariate Analysis
Ligands
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

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Induction Chemoradiotherapy for Locally Advanced Non-small Cell Lung Cancer. / Miura, Akihiro; Sou, Junichi; Shien, Kazuhiko; Yamamoto, Hiromasa; Toyooka, Shinichi.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 71, No. 4, 01.04.2018, p. 270-277.

Research output: Contribution to journalArticle

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abstract = "The management of locally advanced non-small cell lung cancer (LA-NSCLC) is still controversial, because of complicated patient status and poor prognosis. The purpose of this study was to evaluate the treatment results for induction chemoradiotherapy (iCRT) followed by surgery for LA-NSCLC. From 1999 to 2016, 157 patients were surgically treated after iCRT in our hospital, and their median follow-up was 43 months. Overall survival( OS) was 66.8{\%}, and relapse-free survival( RFS) was 52.0{\%}. The poor prognostic factor in OS by multivariate analysis was lower-lobe origin, incomplete radiotherapy, reoperation, and RFS was lower-lobe origin. The result of our hospital was feasible compared with definitive CRT. The definitive CRT is mainstream for treatment of LA-NSCLC and adjuvant anti-programmed death ligand 1 antibody will influence the treatment strategy, however there are some patients who can get benefit only by iCRT followed by surgery. iCRT followed by surgery is one of the feasible treatment for LA-NSCLC.",
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