Induction by parathyroid hormone of ornithine decarboxylase in rabbit costal chondrocytes in culture

Masaharu Takigawa, Rinzo Watanabe, Hiroshi Ishida, Akira Asada, Fujio Suzuki

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The activity of ornithine decarboxylase (ODC) in rabbit costal chondrocytes in culture markedly increased after addition of parathyroid hormone (PTH), reaching a maximum 4 to 5 h after PTH addition. The effect of PTH was dose-dependent both in the presence and absence of fetal calf serum. Addition of cycloheximide or actinomycin D prevented the induction of ODC by PTH. Calcitonin, 1,25-dihydroxyvitamin D3 and vitamin A had no stimulatory effect on the activity of ODC, and did not inhibit the induction of ODC by PTH, when added with PTH.

Original languageEnglish
Pages (from-to)311-314
Number of pages4
JournalJournal of biochemistry
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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