Inducer-specific regulators of tumor necrosis factor alpha production

Hiroyuki Miyachi, Akihiko Azuma, Erika Hioki, Yoshiro Kobayashi, Shigeo Iwasaki, Yuichi Hashimoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Novel potent regulators of tumor necrosis factor alpha (TNF-α) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-α production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate- induced TNF-α production, while they inhibited okadaic acid-induced one.

Original languageEnglish
Pages (from-to)1980-1982
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume44
Issue number10
DOIs
Publication statusPublished - Oct 1996

Keywords

  • HL-60
  • okadaic acid
  • phorbol ester
  • tumor necrosis factor

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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  • Cite this

    Miyachi, H., Azuma, A., Hioki, E., Kobayashi, Y., Iwasaki, S., & Hashimoto, Y. (1996). Inducer-specific regulators of tumor necrosis factor alpha production. Chemical and Pharmaceutical Bulletin, 44(10), 1980-1982. https://doi.org/10.1248/cpb.44.1980