Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-α production

Hiroyuki Miyachi; Akihiko Azuma; Erika Hioki; Shigeo Iwasaki; Yoshiro Kobayashi; Yuichi Hashimoto

doi:10.1006/bbrc.1996.1043

Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-α production

Hiroyuki Miyachi, Akihiko Azuma, Erika Hioki, Shigeo Iwasaki, Yoshiro Kobayashi, Yuichi Hashimoto

Research output: Contribution to journal › Article

43 Citations (Scopus)

Abstract

Regulation by thalidomide [N(α)-phthalimidoglutarimide] of tumor necrosis factor (TNF)-α production was found to be inducer-specific. Thalidomide enhances TNF-α production by human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while it inhibits TNF-α production induced with okadaic acid (OA) in the same cell line. Some phthalimide analogs, including PP-33 [2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione] and its 4,5,6,7-tetrafluoro derivative (FPP-33), also showed such an inducer-specific bidirectional TNF-α production-regulating activity. The structure-activity relationships of the compounds tested are similar, but not identical, in the TPA-stimulated HL-60 and OA-stimulated HL-60 assay systems.

Original language	English
Pages (from-to)	426-430
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	224
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1996.1043
Publication status	Published - Jul 16 1996
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Cite this

Miyachi, H., Azuma, A., Hioki, E., Iwasaki, S., Kobayashi, Y., & Hashimoto, Y. (1996). Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-α production. Biochemical and Biophysical Research Communications, 224(2), 426-430. https://doi.org/10.1006/bbrc.1996.1043

Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-α production. / Miyachi, Hiroyuki; Azuma, Akihiko; Hioki, Erika; Iwasaki, Shigeo; Kobayashi, Yoshiro; Hashimoto, Yuichi.

In: Biochemical and Biophysical Research Communications, Vol. 224, No. 2, 16.07.1996, p. 426-430.

Research output: Contribution to journal › Article

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10.1006/bbrc.1996.1043