Abstract
Regulation by thalidomide [N(α)-phthalimidoglutarimide] of tumor necrosis factor (TNF)-α production was found to be inducer-specific. Thalidomide enhances TNF-α production by human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while it inhibits TNF-α production induced with okadaic acid (OA) in the same cell line. Some phthalimide analogs, including PP-33 [2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione] and its 4,5,6,7-tetrafluoro derivative (FPP-33), also showed such an inducer-specific bidirectional TNF-α production-regulating activity. The structure-activity relationships of the compounds tested are similar, but not identical, in the TPA-stimulated HL-60 and OA-stimulated HL-60 assay systems.
| Original language | English |
|---|---|
| Pages (from-to) | 426-430 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 224 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 16 1996 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Cite this
Miyachi, H., Azuma, A., Hioki, E., Iwasaki, S., Kobayashi, Y., & Hashimoto, Y. (1996). Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-α production. Biochemical and Biophysical Research Communications, 224(2), 426-430. https://doi.org/10.1006/bbrc.1996.1043