Indomethacin inhibits delayed DNA fragmentation of hippocampal CA1 pyramidal neurons after transient forebrain ischemia in gerbils

Fumio Kondo, Yoichi Kondo, Marvin Gómez-Vargas, Norio Ogawa

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Recent studies have shown a close association between reactive oxygen species and DNA fragmentation and that delayed neuronal death after transient forebrain ischemia manifests as DNA fragmentation-like apoptosis. We examined the effect of indomethacin on ischemic-induced delayed hippocampal neuronal death in gerbils using the TUNEL staining method, since indomethacin is neuroprotective in a variety of degenerative processes, such as Alzheimer's disease. Indomethacin (5 mg/kg, i.p.), administered 5 min before the ischemic insult, significantly decreased the number of TUNEL-positive hippocampal CA1 pyramidal neurons and delayed the at appearance of TUNEL-positive neurons. Our results indicate that indomethacin is effective in inhibiting DNA fragmentation after transient forebrain ischemia.

Original languageEnglish
Pages (from-to)352-356
Number of pages5
JournalBrain Research
Volume791
Issue number1-2
DOIs
Publication statusPublished - Apr 27 1998

Keywords

  • Apoptosis
  • Cyclooxygenase
  • Indomethacin
  • Mechanism
  • Transient forebrain ischemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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