Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing

Tiantian Liu, Zhongyan Shi, Jian Zhang, Kexin Wang, Yuanhao Li, Guangying Pei, Li Wang, Jinglong Wu, Tianyi Yan

Research output: Contribution to journalArticlepeer-review

Abstract

Using group-level functional parcellations and constant-length sliding window analysis, dynamic functional connectivity studies have revealed network-specific impairment and compensation in healthy ageing. However, functional parcellation and dynamic time windows vary across individuals; individual-level ageing-related brain dynamics are uncertain. Here, we performed individual parcellation and individual-length sliding window clustering to characterize ageing-related dynamic network changes. Healthy participants (n = 637, 18–88 years) from the Cambridge Centre for Ageing and Neuroscience dataset were included. An individual seven-network parcellation, varied from group-level parcellation, was mapped for each participant. For each network, strong and weak cognitive brain states were revealed by individual-length sliding window clustering and canonical correlation analysis. The results showed negative linear correlations between age and change ratios of sizes in the default mode, frontoparietal, and salience networks and a positive linear correlation between age and change ratios of size in the limbic network (LN). With increasing age, the occurrence and dwell time of strong states showed inverted U-shaped patterns or a linear decreasing pattern in most networks but showed a linear increasing pattern in the LN. Overall, this study reveals a compensative increase in emotional networks (i.e., the LN) and a decline in cognitive and primary sensory networks in healthy ageing. These findings may provide insights into network-specific and individual-level targeting during neuromodulation in ageing and ageing-related diseases.

Original languageEnglish
Pages (from-to)744-761
Number of pages18
JournalHuman Brain Mapping
Volume44
Issue number2
DOIs
Publication statusPublished - Feb 1 2023
Externally publishedYes

Keywords

  • brain states
  • clustering
  • dynamic functional connectivity
  • individual sliding window
  • resting-state fMRI

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing'. Together they form a unique fingerprint.

Cite this