Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma

Akira Takao, Takashi Saika, Shinya Uehara, Koichi Monden, Fernando Abarzua, Yasutomo Nasu, Hiromi Kumon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: To verify the indication of diagnostic ureteropyeloscopy based on clinical features for upper urinary tract urothelial cancer with over 100 patients and over a 10-year series. Methods: From January 1997 to December 2008, consecutive 129 units in 124 patients underwent ureteropyeloscopy to obtain a definitive diagnosis of upper urinary tract cancer or to rule out a malignancy. Patients were divided into four subgroups based on voided urine cytology and preoperative radiographic findings: group A (n = 8), positive urine cytology and positive radiographic findings; group B (n = 4), positive cytology and negative radiographic findings; group C (n = 55), negative cytology and positive radiographic findings and group D (n = 62), gross hematuria originating from the upper urinary tract with negative cytology and negative radiographic findings. Ureteropyeloscopic findings were compared with radiographic and cytological results. Adverse effects were also investigated. Results: In group A, all patients had confirmed cancer. In group B, one revealed small cancer and the remaining three confirmed carcinoma in situ by biopsy with ureteropyeloscopy. In groups C and D, 33 patients (60%) and four (6.5%) revealed cancer. Seventy-eight patients out of 80 (97.5%) in groups C and D were confirmed to have benign disease. No patient was found with malignancy during follow up after negative finding of ureteropyeloscopy. Conclusions: Ureteropyeloscopy can help in detecting upper urinary tract cancer or to rule out malignancy for patients with negative voiding cytology. However, ureteropyeloscopy is redundant for patients with positive radiographic findings and positive voiding cytology.

Original languageEnglish
Article numberhyq096
Pages (from-to)1087-1091
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume40
Issue number11
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Urinary Tract
Cell Biology
Urine
Carcinoma
Urologic Neoplasms
Neoplasms
Carcinoma in Situ
Hematuria
Biopsy

Keywords

  • Diagnosis
  • Indication
  • Upper urinary tract carcinoma
  • Ureteropyeloscopy
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma. / Takao, Akira; Saika, Takashi; Uehara, Shinya; Monden, Koichi; Abarzua, Fernando; Nasu, Yasutomo; Kumon, Hiromi.

In: Japanese Journal of Clinical Oncology, Vol. 40, No. 11, hyq096, 11.2010, p. 1087-1091.

Research output: Contribution to journalArticle

Takao, Akira ; Saika, Takashi ; Uehara, Shinya ; Monden, Koichi ; Abarzua, Fernando ; Nasu, Yasutomo ; Kumon, Hiromi. / Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma. In: Japanese Journal of Clinical Oncology. 2010 ; Vol. 40, No. 11. pp. 1087-1091.
@article{bab0dec52a6341609142be64ba3b1e3c,
title = "Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma",
abstract = "Objective: To verify the indication of diagnostic ureteropyeloscopy based on clinical features for upper urinary tract urothelial cancer with over 100 patients and over a 10-year series. Methods: From January 1997 to December 2008, consecutive 129 units in 124 patients underwent ureteropyeloscopy to obtain a definitive diagnosis of upper urinary tract cancer or to rule out a malignancy. Patients were divided into four subgroups based on voided urine cytology and preoperative radiographic findings: group A (n = 8), positive urine cytology and positive radiographic findings; group B (n = 4), positive cytology and negative radiographic findings; group C (n = 55), negative cytology and positive radiographic findings and group D (n = 62), gross hematuria originating from the upper urinary tract with negative cytology and negative radiographic findings. Ureteropyeloscopic findings were compared with radiographic and cytological results. Adverse effects were also investigated. Results: In group A, all patients had confirmed cancer. In group B, one revealed small cancer and the remaining three confirmed carcinoma in situ by biopsy with ureteropyeloscopy. In groups C and D, 33 patients (60{\%}) and four (6.5{\%}) revealed cancer. Seventy-eight patients out of 80 (97.5{\%}) in groups C and D were confirmed to have benign disease. No patient was found with malignancy during follow up after negative finding of ureteropyeloscopy. Conclusions: Ureteropyeloscopy can help in detecting upper urinary tract cancer or to rule out malignancy for patients with negative voiding cytology. However, ureteropyeloscopy is redundant for patients with positive radiographic findings and positive voiding cytology.",
keywords = "Diagnosis, Indication, Upper urinary tract carcinoma, Ureteropyeloscopy, Urothelial carcinoma",
author = "Akira Takao and Takashi Saika and Shinya Uehara and Koichi Monden and Fernando Abarzua and Yasutomo Nasu and Hiromi Kumon",
year = "2010",
month = "11",
doi = "10.1093/jjco/hyq096",
language = "English",
volume = "40",
pages = "1087--1091",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Indications for ureteropyeloscopy based on radiographic findings and urine cytology in detection of upper urinary tract carcinoma

AU - Takao, Akira

AU - Saika, Takashi

AU - Uehara, Shinya

AU - Monden, Koichi

AU - Abarzua, Fernando

AU - Nasu, Yasutomo

AU - Kumon, Hiromi

PY - 2010/11

Y1 - 2010/11

N2 - Objective: To verify the indication of diagnostic ureteropyeloscopy based on clinical features for upper urinary tract urothelial cancer with over 100 patients and over a 10-year series. Methods: From January 1997 to December 2008, consecutive 129 units in 124 patients underwent ureteropyeloscopy to obtain a definitive diagnosis of upper urinary tract cancer or to rule out a malignancy. Patients were divided into four subgroups based on voided urine cytology and preoperative radiographic findings: group A (n = 8), positive urine cytology and positive radiographic findings; group B (n = 4), positive cytology and negative radiographic findings; group C (n = 55), negative cytology and positive radiographic findings and group D (n = 62), gross hematuria originating from the upper urinary tract with negative cytology and negative radiographic findings. Ureteropyeloscopic findings were compared with radiographic and cytological results. Adverse effects were also investigated. Results: In group A, all patients had confirmed cancer. In group B, one revealed small cancer and the remaining three confirmed carcinoma in situ by biopsy with ureteropyeloscopy. In groups C and D, 33 patients (60%) and four (6.5%) revealed cancer. Seventy-eight patients out of 80 (97.5%) in groups C and D were confirmed to have benign disease. No patient was found with malignancy during follow up after negative finding of ureteropyeloscopy. Conclusions: Ureteropyeloscopy can help in detecting upper urinary tract cancer or to rule out malignancy for patients with negative voiding cytology. However, ureteropyeloscopy is redundant for patients with positive radiographic findings and positive voiding cytology.

AB - Objective: To verify the indication of diagnostic ureteropyeloscopy based on clinical features for upper urinary tract urothelial cancer with over 100 patients and over a 10-year series. Methods: From January 1997 to December 2008, consecutive 129 units in 124 patients underwent ureteropyeloscopy to obtain a definitive diagnosis of upper urinary tract cancer or to rule out a malignancy. Patients were divided into four subgroups based on voided urine cytology and preoperative radiographic findings: group A (n = 8), positive urine cytology and positive radiographic findings; group B (n = 4), positive cytology and negative radiographic findings; group C (n = 55), negative cytology and positive radiographic findings and group D (n = 62), gross hematuria originating from the upper urinary tract with negative cytology and negative radiographic findings. Ureteropyeloscopic findings were compared with radiographic and cytological results. Adverse effects were also investigated. Results: In group A, all patients had confirmed cancer. In group B, one revealed small cancer and the remaining three confirmed carcinoma in situ by biopsy with ureteropyeloscopy. In groups C and D, 33 patients (60%) and four (6.5%) revealed cancer. Seventy-eight patients out of 80 (97.5%) in groups C and D were confirmed to have benign disease. No patient was found with malignancy during follow up after negative finding of ureteropyeloscopy. Conclusions: Ureteropyeloscopy can help in detecting upper urinary tract cancer or to rule out malignancy for patients with negative voiding cytology. However, ureteropyeloscopy is redundant for patients with positive radiographic findings and positive voiding cytology.

KW - Diagnosis

KW - Indication

KW - Upper urinary tract carcinoma

KW - Ureteropyeloscopy

KW - Urothelial carcinoma

UR - http://www.scopus.com/inward/record.url?scp=78049444017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049444017&partnerID=8YFLogxK

U2 - 10.1093/jjco/hyq096

DO - 10.1093/jjco/hyq096

M3 - Article

VL - 40

SP - 1087

EP - 1091

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 11

M1 - hyq096

ER -