Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy

Shuji Suemaru, Keiko Sato, Kiyoshi Morimoto, Norihito Yamada, Toshiki Sato, Shigetoshi Kuroda

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Synapsin is a vesicle-associated protein that is thought to be involved in synaptogenesis and neurotransmitter release. In this study, we investigated the repeated amygdala kindling-induced changes in levels of synapsin I, a marker of enhanced synaptic activity, using immunohistochemistry. Eight hours after the last seizure, synapsin I immunoreactivity (IR) was increased bilaterally in the polymorphic zone of the dentate gyrus, the hilus and the stratum lucidum in area CA3 of the hippocampus. However, 4 weeks after the last kindled seizures, synapsin I IR was not significantly changed in any of the brain regions studied. Therefore, the increased levels of synapsin I protein observed in these brain regions early after the last seizure may reflect the plastic changes that occur in the specific neural networks of the hippocampus directly after kindling- induced seizure activity. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)1319-1322
Number of pages4
JournalNeuroReport
Volume11
Issue number6
Publication statusPublished - Apr 27 2000

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Synapsins
Epilepsy
Hippocampus
Seizures
Dentate Gyrus
Brain
Amygdala
Neurotransmitter Agents
Proteins
Immunohistochemistry

Keywords

  • Amygdala kindling
  • Hippocampus
  • Immunohistochemistry
  • Synapsin I

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Suemaru, S., Sato, K., Morimoto, K., Yamada, N., Sato, T., & Kuroda, S. (2000). Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy. NeuroReport, 11(6), 1319-1322.

Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy. / Suemaru, Shuji; Sato, Keiko; Morimoto, Kiyoshi; Yamada, Norihito; Sato, Toshiki; Kuroda, Shigetoshi.

In: NeuroReport, Vol. 11, No. 6, 27.04.2000, p. 1319-1322.

Research output: Contribution to journalArticle

Suemaru, S, Sato, K, Morimoto, K, Yamada, N, Sato, T & Kuroda, S 2000, 'Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy', NeuroReport, vol. 11, no. 6, pp. 1319-1322.
Suemaru S, Sato K, Morimoto K, Yamada N, Sato T, Kuroda S. Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy. NeuroReport. 2000 Apr 27;11(6):1319-1322.
Suemaru, Shuji ; Sato, Keiko ; Morimoto, Kiyoshi ; Yamada, Norihito ; Sato, Toshiki ; Kuroda, Shigetoshi. / Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy. In: NeuroReport. 2000 ; Vol. 11, No. 6. pp. 1319-1322.
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