Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma

Tsutomu Masaki, Masaaki Tokuda, Makoto Ohnishi, Toshifumi Itano, Hideki Matsui, Seishiro Watanabe, Keiji Arima, Kazumi Kohno, Takashi Maeba, Yuji Tai, Yoshikazu Ikeda, Yoshio Hatanaka, Osamu Hatase, Mikio Nishioka

Research output: Contribution to journalArticle

Abstract

We examined the involvement of src-related tyrosine kinases (RTK) in various human liver diseases, such as chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular careinoma (HCC), by Western blot and immunohistochemical analysis using an anti-src-RTK polyclonal antibody (α-416). Our results showed that src-RTK were rarely found in the liver tissues from CH patients, while they were found at high amounts in those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK may play important roles in the occurrence and development of LC and HCC.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalInternational Hepatology Communications
Volume4
Issue number1
DOIs
Publication statusPublished - Jul 1995

Keywords

  • Hepatocellular carcinoma
  • Liver cirrhosis
  • Src products

ASJC Scopus subject areas

  • Hepatology

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    Masaki, T., Tokuda, M., Ohnishi, M., Itano, T., Matsui, H., Watanabe, S., Arima, K., Kohno, K., Maeba, T., Tai, Y., Ikeda, Y., Hatanaka, Y., Hatase, O., & Nishioka, M. (1995). Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma. International Hepatology Communications, 4(1), 54-60. https://doi.org/10.1016/0928-4346(95)00206-X