Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma

Tsutomu Masaki; Masaaki Tokuda; Makoto Ohnishi; Toshifumi Itano; Hideki Matsui; Seishiro Watanabe; Keiji Arima; Kazumi Kohno; Takashi Maeba; Yuji Tai; Yoshikazu Ikeda; Yoshio Hatanaka; Osamu Hatase; Mikio Nishioka

doi:10.1016/0928-4346(95)00206-X

Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma

Tsutomu Masaki, Masaaki Tokuda, Makoto Ohnishi, Toshifumi Itano, Hideki Matsui, Seishiro Watanabe, Keiji Arima, Kazumi Kohno, Takashi Maeba, Yuji Tai, Yoshikazu Ikeda, Yoshio Hatanaka, Osamu Hatase, Mikio Nishioka

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We examined the involvement of src-related tyrosine kinases (RTK) in various human liver diseases, such as chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular careinoma (HCC), by Western blot and immunohistochemical analysis using an anti-src-RTK polyclonal antibody (α-416). Our results showed that src-RTK were rarely found in the liver tissues from CH patients, while they were found at high amounts in those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK may play important roles in the occurrence and development of LC and HCC.

Original language	English
Pages (from-to)	54-60
Number of pages	7
Journal	International Hepatology Communications
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/0928-4346(95)00206-X
Publication status	Published - Jul 1995

Keywords

Hepatocellular carcinoma
Liver cirrhosis
Src products

ASJC Scopus subject areas

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0928-4346(95)00206-X

Cite this

Masaki, T., Tokuda, M., Ohnishi, M., Itano, T., Matsui, H., Watanabe, S., Arima, K., Kohno, K., Maeba, T., Tai, Y., Ikeda, Y., Hatanaka, Y., Hatase, O., & Nishioka, M. (1995). Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma. International Hepatology Communications, 4(1), 54-60. https://doi.org/10.1016/0928-4346(95)00206-X

Masaki, T, Tokuda, M, Ohnishi, M, Itano, T, Matsui, H, Watanabe, S, Arima, K, Kohno, K, Maeba, T, Tai, Y, Ikeda, Y, Hatanaka, Y, Hatase, O & Nishioka, M 1995, 'Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma', International Hepatology Communications, vol. 4, no. 1, pp. 54-60. https://doi.org/10.1016/0928-4346(95)00206-X

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title = "Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma",

abstract = "We examined the involvement of src-related tyrosine kinases (RTK) in various human liver diseases, such as chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular careinoma (HCC), by Western blot and immunohistochemical analysis using an anti-src-RTK polyclonal antibody (α-416). Our results showed that src-RTK were rarely found in the liver tissues from CH patients, while they were found at high amounts in those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK may play important roles in the occurrence and development of LC and HCC.",

keywords = "Hepatocellular carcinoma, Liver cirrhosis, Src products",

author = "Tsutomu Masaki and Masaaki Tokuda and Makoto Ohnishi and Toshifumi Itano and Hideki Matsui and Seishiro Watanabe and Keiji Arima and Kazumi Kohno and Takashi Maeba and Yuji Tai and Yoshikazu Ikeda and Yoshio Hatanaka and Osamu Hatase and Mikio Nishioka",

note = "Funding Information: We thank the staff of the Common Equipment Research Center of Kagawa Medical School for their technical assistance. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.",

year = "1995",

month = jul,

doi = "10.1016/0928-4346(95)00206-X",

language = "English",

volume = "4",

pages = "54--60",

journal = "Hepatology Research",

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T1 - Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma

AU - Masaki, Tsutomu

AU - Tokuda, Masaaki

AU - Ohnishi, Makoto

AU - Itano, Toshifumi

AU - Matsui, Hideki

AU - Watanabe, Seishiro

AU - Arima, Keiji

AU - Kohno, Kazumi

AU - Maeba, Takashi

AU - Tai, Yuji

AU - Ikeda, Yoshikazu

AU - Hatanaka, Yoshio

AU - Hatase, Osamu

AU - Nishioka, Mikio

N1 - Funding Information: We thank the staff of the Common Equipment Research Center of Kagawa Medical School for their technical assistance. This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

PY - 1995/7

Y1 - 1995/7

N2 - We examined the involvement of src-related tyrosine kinases (RTK) in various human liver diseases, such as chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular careinoma (HCC), by Western blot and immunohistochemical analysis using an anti-src-RTK polyclonal antibody (α-416). Our results showed that src-RTK were rarely found in the liver tissues from CH patients, while they were found at high amounts in those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK may play important roles in the occurrence and development of LC and HCC.

AB - We examined the involvement of src-related tyrosine kinases (RTK) in various human liver diseases, such as chronic hepatitis (CH), liver cirrhosis (LC) and hepatocellular careinoma (HCC), by Western blot and immunohistochemical analysis using an anti-src-RTK polyclonal antibody (α-416). Our results showed that src-RTK were rarely found in the liver tissues from CH patients, while they were found at high amounts in those from LC and HCC patients. In addition, src-RTK were expressed more strongly in HCC than in LC. These results indicate that src-RTK may play important roles in the occurrence and development of LC and HCC.

KW - Hepatocellular carcinoma

KW - Liver cirrhosis

KW - Src products

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DO - 10.1016/0928-4346(95)00206-X

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SN - 1386-6346

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JO - Hepatology Research

JF - Hepatology Research

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Increases in src-related protein tyrosine kinases in human liver cirrhosis and hepatocellular carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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