Increases in mRNA levels for Tα1-tubulin in the rat kindling model of epilepsy

Keiko Sato, Koji Abe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The expression of mRNA for Tα1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Tα1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalBrain Research
Volume904
Issue number1
DOIs
Publication statusPublished - Jun 15 2001

Keywords

  • Cytoskeletal protien
  • Kindling
  • Neural plasticity
  • Temporal lobe epilepsy
  • Tα1-tubulin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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