TY - JOUR
T1 - Increases in mRNA levels for Tα1-tubulin in the rat kindling model of epilepsy
AU - Sato, Keiko
AU - Abe, Koji
N1 - Funding Information:
We thank Professor Koichi Tanaka, Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University for his advice on the method of this work. This work was partly supported by Grant-in-Aid for Scientific Research (B) 12470141 and (Hohga) 12877211 from the Ministry of Education, Science and Culture of Japan.
PY - 2001/6/15
Y1 - 2001/6/15
N2 - The expression of mRNA for Tα1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Tα1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity.
AB - The expression of mRNA for Tα1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Tα1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity.
KW - Cytoskeletal protien
KW - Kindling
KW - Neural plasticity
KW - Temporal lobe epilepsy
KW - Tα1-tubulin
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U2 - 10.1016/S0006-8993(01)02459-3
DO - 10.1016/S0006-8993(01)02459-3
M3 - Article
C2 - 11516424
AN - SCOPUS:0035876027
VL - 904
SP - 157
EP - 160
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 1
ER -