Abstract
The expression of mRNA for Tα1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Tα1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity.
| Original language | English |
|---|---|
| Pages (from-to) | 157-160 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 904 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jun 15 2001 |
Fingerprint
Keywords
- Cytoskeletal protien
- Kindling
- Neural plasticity
- Tα1-tubulin
- Temporal lobe epilepsy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Increases in mRNA levels for Tα1-tubulin in the rat kindling model of epilepsy. / Sato, Keiko; Abe, Koji.
In: Brain Research, Vol. 904, No. 1, 15.06.2001, p. 157-160.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increases in mRNA levels for Tα1-tubulin in the rat kindling model of epilepsy
AU - Sato, Keiko
AU - Abe, Koji
PY - 2001/6/15
Y1 - 2001/6/15
N2 - The expression of mRNA for Tα1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Tα1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity.
AB - The expression of mRNA for Tα1-tubulin, a cytoskeletal protein, was studied in the rat kindling model of epilepsy. The Tα1-tubulin mRNA level increased significantly in the dentate gyrus (DG) and CA3 of hippocampus ipsilateral to stimulation from 8 h to 4 weeks after amygdaloid kindled seizures. The peak increase was observed at 1 week after the last seizures both in the DG and CA3. These results suggest that the microtubule formation contributes to synaptic remodeling and reorganization of neural networks, which may be based on the kindling-inducing epileptogenesity.
KW - Cytoskeletal protien
KW - Kindling
KW - Neural plasticity
KW - Tα1-tubulin
KW - Temporal lobe epilepsy
UR - http://www.scopus.com/inward/record.url?scp=0035876027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035876027&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(01)02459-3
DO - 10.1016/S0006-8993(01)02459-3
M3 - Article
C2 - 11516424
AN - SCOPUS:0035876027
VL - 904
SP - 157
EP - 160
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -