Increased synapsin I immunoreactivity during long-term potentiation in rat hippocampus

Keiko Sato, Kiyoshi Morimoto, Shuji Suemaru, Toshiki Sato, Norihito Yamada

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The level of synapsin I, a synaptic vesicle protein and marker for synaptic activation, was studied 8 h after long-term potentiation (LTP) induction in rat hippocampus in vivo. Quantitative immunohistochemical analysis revealed that synapsin I increased significantly in the molecular layer of the dentate gyrus and the stratum lucidum of CA3, suggesting activation of the granule cells by synaptic input to the dentate gyrus, and persistent enhancement of glutamate release from the axon terminals of the dentate granule cells. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalBrain Research
Issue number1-2
Publication statusPublished - Jul 28 2000


  • Hippocampus
  • Immunohistochemistry
  • Long-term potentiation
  • Quantitative analysis
  • Synapsin I

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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