Abstract
After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.
| Original language | English |
|---|---|
| Pages (from-to) | 299-306 |
| Number of pages | 8 |
| Journal | Free Radical Biology and Medicine |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1991 |
Fingerprint
Keywords
- 2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl
- 5,5-Dimethyl-l-pyrroline N-oxide
- BCA
- Bicinchoninic
- Decrease in lipid peroxides
- DETAPAC
- Diethylenetriaminepentaacetic acid
- DMPO
- Electron spin resonance
- ESR
- Free radicals
- HPX
- Hypoxanthine
- Induction of SOD
- Low dose irradiation
- SOD
- Superoxide dismutase
- TBARS
- TEMPOL
- Thiobarbituric acid reacting substances
- Xanthine-oxidase
- XOD
ASJC Scopus subject areas
- Clinical Biochemistry
- Medicine(all)
- Toxicology
Cite this
Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs. / Yamaoka, Kiyonori; Edamatsu, Rei; Mori, Akitane.
In: Free Radical Biology and Medicine, Vol. 11, No. 3, 1991, p. 299-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs
AU - Yamaoka, Kiyonori
AU - Edamatsu, Rei
AU - Mori, Akitane
PY - 1991
Y1 - 1991
N2 - After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.
AB - After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.
KW - 2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl
KW - 5,5-Dimethyl-l-pyrroline N-oxide
KW - BCA
KW - Bicinchoninic
KW - Decrease in lipid peroxides
KW - DETAPAC
KW - Diethylenetriaminepentaacetic acid
KW - DMPO
KW - Electron spin resonance
KW - ESR
KW - Free radicals
KW - HPX
KW - Hypoxanthine
KW - Induction of SOD
KW - Low dose irradiation
KW - SOD
KW - Superoxide dismutase
KW - TBARS
KW - TEMPOL
KW - Thiobarbituric acid reacting substances
KW - Xanthine-oxidase
KW - XOD
UR - http://www.scopus.com/inward/record.url?scp=0025887843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025887843&partnerID=8YFLogxK
U2 - 10.1016/0891-5849(91)90127-O
DO - 10.1016/0891-5849(91)90127-O
M3 - Article
C2 - 1937147
AN - SCOPUS:0025887843
VL - 11
SP - 299
EP - 306
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
SN - 0891-5849
IS - 3
ER -