Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs

Kiyonori Yamaoka, Rei Edamatsu, Akitane Mori

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Abstract

After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p < 0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalFree Radical Biology and Medicine
Volume11
Issue number3
DOIs
Publication statusPublished - 1991

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Keywords

  • 2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl
  • 5,5-Dimethyl-l-pyrroline N-oxide
  • BCA
  • Bicinchoninic
  • DETAPAC
  • DMPO
  • Decrease in lipid peroxides
  • Diethylenetriaminepentaacetic acid
  • ESR
  • Electron spin resonance
  • Free radicals
  • HPX
  • Hypoxanthine
  • Induction of SOD
  • Low dose irradiation
  • SOD
  • Superoxide dismutase
  • TBARS
  • TEMPOL
  • Thiobarbituric acid reacting substances
  • XOD
  • Xanthine-oxidase

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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