Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs

Kiyonori Yamaoka, Rei Edamatsu, Akitane Mori

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalFree Radical Biology and Medicine
Volume11
Issue number3
DOIs
Publication statusPublished - 1991

Fingerprint

Lipid Peroxides
Dosimetry
Rats
Brain
Irradiation
Liver
Thymus
Thymus Gland
Bone
Bone Marrow
Control Groups
Whole-Body Irradiation
Spleen
Radiation

Keywords

  • 2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl
  • 5,5-Dimethyl-l-pyrroline N-oxide
  • BCA
  • Bicinchoninic
  • Decrease in lipid peroxides
  • DETAPAC
  • Diethylenetriaminepentaacetic acid
  • DMPO
  • Electron spin resonance
  • ESR
  • Free radicals
  • HPX
  • Hypoxanthine
  • Induction of SOD
  • Low dose irradiation
  • SOD
  • Superoxide dismutase
  • TBARS
  • TEMPOL
  • Thiobarbituric acid reacting substances
  • Xanthine-oxidase
  • XOD

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine(all)
  • Toxicology

Cite this

Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs. / Yamaoka, Kiyonori; Edamatsu, Rei; Mori, Akitane.

In: Free Radical Biology and Medicine, Vol. 11, No. 3, 1991, p. 299-306.

Research output: Contribution to journalArticle

@article{cc68c2319ff04aef82d760005dc512eb,
title = "Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs",
abstract = "After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90{\%} (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50{\%} for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50{\%} in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30{\%} were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.",
keywords = "2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl, 5,5-Dimethyl-l-pyrroline N-oxide, BCA, Bicinchoninic, Decrease in lipid peroxides, DETAPAC, Diethylenetriaminepentaacetic acid, DMPO, Electron spin resonance, ESR, Free radicals, HPX, Hypoxanthine, Induction of SOD, Low dose irradiation, SOD, Superoxide dismutase, TBARS, TEMPOL, Thiobarbituric acid reacting substances, Xanthine-oxidase, XOD",
author = "Kiyonori Yamaoka and Rei Edamatsu and Akitane Mori",
year = "1991",
doi = "10.1016/0891-5849(91)90127-O",
language = "English",
volume = "11",
pages = "299--306",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs

AU - Yamaoka, Kiyonori

AU - Edamatsu, Rei

AU - Mori, Akitane

PY - 1991

Y1 - 1991

N2 - After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

AB - After a single exposure to doses ranging from 0.05 to 0.50 Gy, the SOD activities]in immune organs of the irradiated rats, at 4 h after whole-body X irradiation, showed significant increases by 50 to 90% (hereinafter p <0.05) in comparison with the control groups. The dose in the brain and liver showed tendencies to increase by 30 to 50% for doses ranging from 0.50 to 2.50 Gy. The levels of TBARS (lipid peroxides) in immune organs decreased significantly by 20 to 50% in contrast with the control groups for doses ranging from 0.10 to 1.00 Gy. Decreases by 20 to 30% were observed in brains and livers for doses near 0.50 Gy. When the dose was 0.25 Gy, the SOD activities in the spleen showed a persistent radiation-induced increase for at least 12 weeks, livers for 8 weeks, brains and thymuses for 4 weeks, and bone marrows for about 1 week. The TBARS levels in the brain and thymus showed persistent decreases due to irradiation for at least 12 weeks, and those in bone marrows for 8 h.

KW - 2,2,6,6-tetramethyl-4-hydroxylpiperidine-l-oxyl

KW - 5,5-Dimethyl-l-pyrroline N-oxide

KW - BCA

KW - Bicinchoninic

KW - Decrease in lipid peroxides

KW - DETAPAC

KW - Diethylenetriaminepentaacetic acid

KW - DMPO

KW - Electron spin resonance

KW - ESR

KW - Free radicals

KW - HPX

KW - Hypoxanthine

KW - Induction of SOD

KW - Low dose irradiation

KW - SOD

KW - Superoxide dismutase

KW - TBARS

KW - TEMPOL

KW - Thiobarbituric acid reacting substances

KW - Xanthine-oxidase

KW - XOD

UR - http://www.scopus.com/inward/record.url?scp=0025887843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025887843&partnerID=8YFLogxK

U2 - 10.1016/0891-5849(91)90127-O

DO - 10.1016/0891-5849(91)90127-O

M3 - Article

C2 - 1937147

AN - SCOPUS:0025887843

VL - 11

SP - 299

EP - 306

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - 3

ER -