Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease

Koichi Waseda, Kazuki Ocho, Kou Hasegawa, Kosuke Kimura, Masaya Iwamuro, Yoshihisa Hanayama, Eisei Kondo, Nobuaki Miyahara, Fumio Otsuka

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalActa Medica Okayama
Volume70
Issue number3
Publication statusPublished - 2016

Fingerprint

Mycobacterium avium Complex
Pulmonary diseases
Lung Diseases
Interstitial Lung Diseases
Rheumatoid Arthritis
Prednisolone
Lung
Infection
Serum
Thorax
Glycoproteins
Alveolar Epithelial Cells
Recurrence
Alveolar Macrophages
Documentation
Therapeutics

Keywords

  • Bronchial alveolar lavage
  • KL-6
  • Mycobacterium avium complex
  • Pulmonary nontuberculous mycobacterium infection
  • Rheumatoid arthritis-associated interstitial lung disease

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease. / Waseda, Koichi; Ocho, Kazuki; Hasegawa, Kou; Kimura, Kosuke; Iwamuro, Masaya; Hanayama, Yoshihisa; Kondo, Eisei; Miyahara, Nobuaki; Otsuka, Fumio.

In: Acta Medica Okayama, Vol. 70, No. 3, 2016, p. 217-222.

Research output: Contribution to journal › Article

Waseda, K, Ocho, K, Hasegawa, K, Kimura, K, Iwamuro, M, Hanayama, Y, Kondo, E, Miyahara, N & Otsuka, F 2016, 'Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease', Acta Medica Okayama, vol. 70, no. 3, pp. 217-222.
Waseda K, Ocho K, Hasegawa K, Kimura K, Iwamuro M, Hanayama Y et al. Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease. Acta Medica Okayama. 2016;70(3):217-222.
Waseda, Koichi ; Ocho, Kazuki ; Hasegawa, Kou ; Kimura, Kosuke ; Iwamuro, Masaya ; Hanayama, Yoshihisa ; Kondo, Eisei ; Miyahara, Nobuaki ; Otsuka, Fumio. / Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease. In: Acta Medica Okayama. 2016 ; Vol. 70, No. 3. pp. 217-222.
@article{908790ee9d23475ea3426b9304ddd0de,
title = "Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease",
abstract = "KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.",
keywords = "Bronchial alveolar lavage, KL-6, Mycobacterium avium complex, Pulmonary nontuberculous mycobacterium infection, Rheumatoid arthritis-associated interstitial lung disease",
author = "Koichi Waseda and Kazuki Ocho and Kou Hasegawa and Kosuke Kimura and Masaya Iwamuro and Yoshihisa Hanayama and Eisei Kondo and Nobuaki Miyahara and Fumio Otsuka",
year = "2016",
language = "English",
volume = "70",
pages = "217--222",
journal = "Acta Medica Okayama",
issn = "0386-300X",
publisher = "Okayama University",
number = "3",

}

TY - JOUR

T1 - Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease

AU - Waseda, Koichi

AU - Ocho, Kazuki

AU - Hasegawa, Kou

AU - Kimura, Kosuke

AU - Iwamuro, Masaya

AU - Hanayama, Yoshihisa

AU - Kondo, Eisei

AU - Miyahara, Nobuaki

AU - Otsuka, Fumio

PY - 2016

Y1 - 2016

N2 - KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.

AB - KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.

KW - Bronchial alveolar lavage

KW - KL-6

KW - Mycobacterium avium complex

KW - Pulmonary nontuberculous mycobacterium infection

KW - Rheumatoid arthritis-associated interstitial lung disease

UR - http://www.scopus.com/inward/record.url?scp=84984851135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984851135&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84984851135

VL - 70

SP - 217

EP - 222

JO - Acta Medica Okayama

JF - Acta Medica Okayama

SN - 0386-300X

IS - 3

ER -

Access to Document