Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter

Masayuki Tatemichi, Tomohiro Sawa, Isabelle Gilibert, Hiroshi Tazawa, Takahiko Katoh, Hiroshi Ohshima

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Tandem repeat number polymorphism of a CCTTT pentanucleotide in the promoter region of the inducible nitric oxide synthase gene (iNOS) and a polymorphism of the interleukin-1β (IL-1B) promoter at position -31 were analyzed in DNA samples from 181 Japanese control subjects and 158 gastric cancer patients, including 96 intestinal type and 62 diffuse type. An association between the intestinal type of gastric adenocarcinoma and higher promoter activity of the iNOS gene was found in women, especially those having higher promoter activity of the IL-1B gene and without a history of smoking. Our results imply that chronic inflammation caused by excess nitric oxide generated by iNOS contributes to Helicobacter pylori-induced gastric cancer.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalCancer Letters
Volume217
Issue number2
DOIs
Publication statusPublished - Jan 20 2005
Externally publishedYes

Fingerprint

Nitric Oxide Synthase Type II
Microsatellite Repeats
Stomach
Adenocarcinoma
Genes
Stomach Neoplasms
Tandem Repeat Sequences
Interleukin-1
Genetic Promoter Regions
Helicobacter pylori
Nitric Oxide
Smoking
Inflammation
DNA

Keywords

  • Gastric cancer
  • Inducible nitric oxide synthase
  • Inflammation
  • Interleukin-1β
  • Tandem repeat number polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter. / Tatemichi, Masayuki; Sawa, Tomohiro; Gilibert, Isabelle; Tazawa, Hiroshi; Katoh, Takahiko; Ohshima, Hiroshi.

In: Cancer Letters, Vol. 217, No. 2, 20.01.2005, p. 197-202.

Research output: Contribution to journalArticle

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AU - Tazawa, Hiroshi

AU - Katoh, Takahiko

AU - Ohshima, Hiroshi

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