Increased oxidative stress in childhood atopic dermatitis

Nemuko Omata, Hirokazu Tsukahara, Setsuko Ito, Yusei Ohshima, Mokoto Yasutomi, Akiko Yamada, Mizu Jiang, Masahiro Hiraoka, Mitsuhiko Nambu, Yoji Deguchi, Mitsufumi Mayumi

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102 Citations (Scopus)

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease of unknown etiology. To examine the involvement of impaired homeostasis of oxygen/nitrogen radicals in childhood AD, we compared the levels of urinary 8-hydroxy-2′-deoxyguanosine (marker of oxidative stress), nitrite/nitrate (marker of nitric oxide synthesis) and selenium (marker of selenium store) in 27 children with AD to those of 25 healthy control children. Urinary 8-hydroxy-2′-deoxyguanosine was significantly higher and nitrite/nitrate levels were significantly lower in patients with AD than in the control. Urinary selenium levels were similar in both groups. Our findings suggest that impaired homeostasis of oxygen/nitrogen radicals and increased oxidative stress are involved in the pathophysiology of childhood AD, and indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalLife Sciences
Volume69
Issue number2
DOIs
Publication statusPublished - Jun 1 2001
Externally publishedYes

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Keywords

  • 8-Hydroxy-2′-deoxyguanosine
  • Atopic dermatitis
  • Children
  • Nitric oxide
  • Oxidative stress
  • Selenium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Omata, N., Tsukahara, H., Ito, S., Ohshima, Y., Yasutomi, M., Yamada, A., Jiang, M., Hiraoka, M., Nambu, M., Deguchi, Y., & Mayumi, M. (2001). Increased oxidative stress in childhood atopic dermatitis. Life Sciences, 69(2), 223-228. https://doi.org/10.1016/S0024-3205(01)01124-9