Increased oxidative stress in childhood atopic dermatitis

Nemuko Omata, Hirokazu Tsukahara, Setsuko Ito, Yusei Ohshima, Mokoto Yasutomi, Akiko Yamada, Mizu Jiang, Masahiro Hiraoka, Mitsuhiko Nambu, Yoji Deguchi, Mitsufumi Mayumi

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)


Atopic dermatitis (AD) is a chronic inflammatory skin disease of unknown etiology. To examine the involvement of impaired homeostasis of oxygen/nitrogen radicals in childhood AD, we compared the levels of urinary 8-hydroxy-2′-deoxyguanosine (marker of oxidative stress), nitrite/nitrate (marker of nitric oxide synthesis) and selenium (marker of selenium store) in 27 children with AD to those of 25 healthy control children. Urinary 8-hydroxy-2′-deoxyguanosine was significantly higher and nitrite/nitrate levels were significantly lower in patients with AD than in the control. Urinary selenium levels were similar in both groups. Our findings suggest that impaired homeostasis of oxygen/nitrogen radicals and increased oxidative stress are involved in the pathophysiology of childhood AD, and indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalLife Sciences
Issue number2
Publication statusPublished - Jun 1 2001
Externally publishedYes


  • 8-Hydroxy-2′-deoxyguanosine
  • Atopic dermatitis
  • Children
  • Nitric oxide
  • Oxidative stress
  • Selenium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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