Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas

Kimio Yoshizato, Jun Ichi Kuratsu, Hideo Takeshima, Toru Nishi, Teizo Yoshimura, Yukitaka Ushio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that MCP-1 expression was highly induced by tumor necrosis factor-α (TNFα) and interleukin-1β. The intra-tumoral injection of TNFα in rat glioma model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection and induced macrophage infiltration into tumor tissue. The injection of TNFα into post-operative tumor cavity of human malignant glioma also increased the concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These data, together with the previous finding that the growth of transplanted MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, suggest that injection of TNFα inhibits tumor growth via the induction of MCP-1 expression.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalInternational journal of oncology
Volume8
Issue number3
Publication statusPublished - Mar 1 1996
Externally publishedYes

Keywords

  • Glioma
  • Macrophage infiltration
  • Monocyte chemoattractant protein-1
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas'. Together they form a unique fingerprint.

  • Cite this

    Yoshizato, K., Kuratsu, J. I., Takeshima, H., Nishi, T., Yoshimura, T., & Ushio, Y. (1996). Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas. International journal of oncology, 8(3), 493-497.