Increased local connectivity of brain functional networks during facial processing in schizophrenia: Evidence from EEG data

Tianyi Yan, Wenhui Wang, Tiantian Liu, Duanduan Chen, Changming Wang, Yulong Li, Xudong Ma, Xiaoying Tang, Jinglong Wu, Yiming Deng, Lun Zhao

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Schizophrenia is often considered to be a disconnection syndrome. The abnormal interactions between large-scale functional brain networks result in cognitive and perceptual deficits. The present study investigated event-related functional connectivity networks to compare facial processing in individuals with and without schizophrenia. Faces and tables were presented to participants, and event-related phase synchrony, represented by the phase lag index (PLI), was calculated. In addition, cortical oscillatory dynamics may be useful for understanding the neural mechanisms underlying the disparate cognitive and functional impairments in schizophrenic patients. Therefore, the dynamic graph theoretical networks related to facial processing were compared between individuals with and without schizophrenia. Our results showed that event-related phase synchrony was significantly reduced in distributed networks, and normalized clustering coefficients were significantly increased in schizophrenic patients relative to those of the controls. The present data suggest that schizophrenic patients have specific alterations, indicated by increased local connectivity in gamma oscillations during facial processing.

Original languageEnglish
Pages (from-to)107312-107322
Number of pages11
JournalOncotarget
Volume8
Issue number63
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Dynamic brain network
  • Facial processing
  • Graph theory
  • Phase synchrony
  • Schizophrenia

ASJC Scopus subject areas

  • Oncology

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    Yan, T., Wang, W., Liu, T., Chen, D., Wang, C., Li, Y., Ma, X., Tang, X., Wu, J., Deng, Y., & Zhao, L. (2017). Increased local connectivity of brain functional networks during facial processing in schizophrenia: Evidence from EEG data. Oncotarget, 8(63), 107312-107322. https://doi.org/10.18632/oncotarget.20598