Abstract
Surgical bleeding associated with splanchnic hyperaemia due to portal hypertension complicates the anaesthetic management of hepatic transplantation. Although the mechanism(s) of portal hypertension are not fully understood, carbon monoxide, a product of the heme oxygenase (HO) reaction, is thought to be one of the endogenous vasodilators in the liver. In this study, the expression of mRNA encoding inducible HO isozyme (HO-1) in the livers of patients with portal hypertension undergoing hepatic transplantation was determined in comparison with those without portal hypertension. HO-1 mRNA levels were significantly greater in the portal hypertension group than in the group without portal hypertension. In contrast with HO-1, the gene expression of non-specific δ-amino-levulinate synthase (ALAS-N), which is down-regulated by heme in the liver, was the same in both groups. These results suggest that HO-1 is up-regulated through heme-independent stimuli according to the development of portal hypertension, and that induced HO-1 plays a pathophysiological role in portal hypertension through carbon monoxide production.
| Original language | English |
|---|---|
| Pages (from-to) | 282-288 |
| Number of pages | 7 |
| Journal | Journal of International Medical Research |
| Volume | 30 |
| Issue number | 3 |
| Publication status | Published - 2002 |
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Keywords
- Gene expression
- Heme oxygenase-1
- Hepatic transplantation
- Liver cirrhosis
- Non-specific δ-aminolevulinate synthase
- Portal hypertension
ASJC Scopus subject areas
- Medicine(all)
Cite this
Increased heme oxygenase-1 gene expression in the livers of patients with portal hypertension due to severe hepatic cirrhosis. / Matsumi, M.; Takahashi, T.; Fujii, H.; Ohashi, I.; Kaku, Ryuji; Nakatsuka, H.; Shimizu, H.; Morita, K.; Hirakawa, M.; Inagaki, M.; Sadamori, H.; Yagi, Takahito; Tanaka, N.; Akagi, R.
In: Journal of International Medical Research, Vol. 30, No. 3, 2002, p. 282-288.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased heme oxygenase-1 gene expression in the livers of patients with portal hypertension due to severe hepatic cirrhosis
AU - Matsumi, M.
AU - Takahashi, T.
AU - Fujii, H.
AU - Ohashi, I.
AU - Kaku, Ryuji
AU - Nakatsuka, H.
AU - Shimizu, H.
AU - Morita, K.
AU - Hirakawa, M.
AU - Inagaki, M.
AU - Sadamori, H.
AU - Yagi, Takahito
AU - Tanaka, N.
AU - Akagi, R.
PY - 2002
Y1 - 2002
N2 - Surgical bleeding associated with splanchnic hyperaemia due to portal hypertension complicates the anaesthetic management of hepatic transplantation. Although the mechanism(s) of portal hypertension are not fully understood, carbon monoxide, a product of the heme oxygenase (HO) reaction, is thought to be one of the endogenous vasodilators in the liver. In this study, the expression of mRNA encoding inducible HO isozyme (HO-1) in the livers of patients with portal hypertension undergoing hepatic transplantation was determined in comparison with those without portal hypertension. HO-1 mRNA levels were significantly greater in the portal hypertension group than in the group without portal hypertension. In contrast with HO-1, the gene expression of non-specific δ-amino-levulinate synthase (ALAS-N), which is down-regulated by heme in the liver, was the same in both groups. These results suggest that HO-1 is up-regulated through heme-independent stimuli according to the development of portal hypertension, and that induced HO-1 plays a pathophysiological role in portal hypertension through carbon monoxide production.
AB - Surgical bleeding associated with splanchnic hyperaemia due to portal hypertension complicates the anaesthetic management of hepatic transplantation. Although the mechanism(s) of portal hypertension are not fully understood, carbon monoxide, a product of the heme oxygenase (HO) reaction, is thought to be one of the endogenous vasodilators in the liver. In this study, the expression of mRNA encoding inducible HO isozyme (HO-1) in the livers of patients with portal hypertension undergoing hepatic transplantation was determined in comparison with those without portal hypertension. HO-1 mRNA levels were significantly greater in the portal hypertension group than in the group without portal hypertension. In contrast with HO-1, the gene expression of non-specific δ-amino-levulinate synthase (ALAS-N), which is down-regulated by heme in the liver, was the same in both groups. These results suggest that HO-1 is up-regulated through heme-independent stimuli according to the development of portal hypertension, and that induced HO-1 plays a pathophysiological role in portal hypertension through carbon monoxide production.
KW - Gene expression
KW - Heme oxygenase-1
KW - Hepatic transplantation
KW - Liver cirrhosis
KW - Non-specific δ-aminolevulinate synthase
KW - Portal hypertension
UR - http://www.scopus.com/inward/record.url?scp=0035988476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035988476&partnerID=8YFLogxK
M3 - Article
C2 - 12166345
AN - SCOPUS:0035988476
VL - 30
SP - 282
EP - 288
JO - Journal of International Medical Research
JF - Journal of International Medical Research
SN - 0300-0605
IS - 3
ER -