Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

Shusei Yamamoto; Ikumi Sato; Moe Fujii; Mai Kakimoto; Koki Honma; Natsumi Akiyama; Miku Sakai; Natsuki Fukuhama; Shota Kumazaki; Satoshi Hirohata; Kazuya Kitamori; Yukio Yamori; Shogo Watanabe

doi:10.18926/AMO/64358

Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Natsumi Akiyama, Miku Sakai, Natsuki Fukuhama, Shota Kumazaki, Satoshi Hirohata, Kazuya Kitamori, Yukio Yamori, Shogo Watanabe

Research output: Contribution to journal › Article › peer-review

Abstract

The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.

Original language	English
Pages (from-to)	29-36
Number of pages	8
Journal	Acta medica Okayama
Volume	77
Issue number	1
DOIs	https://doi.org/10.18926/AMO/64358
Publication status	Published - Feb 1 2023

Keywords

cardiovascular disease
glycine-conjugated bile acids
nonalcoholic steatohepatitis
SHRSP5/Dmc
unconjugated bile acids

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18926/AMO/64358

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Yamamoto, S., Sato, I., Fujii, M., Kakimoto, M., Honma, K., Akiyama, N., Sakai, M., Fukuhama, N., Kumazaki, S., Hirohata, S., Kitamori, K., Yamori, Y., & Watanabe, S. (2023). Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat. Acta medica Okayama, 77(1), 29-36. https://doi.org/10.18926/AMO/64358

Yamamoto, S, Sato, I, Fujii, M, Kakimoto, M, Honma, K, Akiyama, N, Sakai, M, Fukuhama, N, Kumazaki, S, Hirohata, S, Kitamori, K, Yamori, Y & Watanabe, S 2023, 'Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat', Acta medica Okayama, vol. 77, no. 1, pp. 29-36. https://doi.org/10.18926/AMO/64358

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abstract = "The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.",

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AU - Sato, Ikumi

AU - Fujii, Moe

AU - Kakimoto, Mai

AU - Honma, Koki

AU - Akiyama, Natsumi

AU - Sakai, Miku

AU - Fukuhama, Natsuki

AU - Kumazaki, Shota

AU - Hirohata, Satoshi

AU - Kitamori, Kazuya

AU - Yamori, Yukio

AU - Watanabe, Shogo

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KW - glycine-conjugated bile acids

KW - nonalcoholic steatohepatitis

KW - SHRSP5/Dmc

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Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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