Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues

Nur Mohammad Monsur Hassan, Jun Ichi Hamada, Takeshi Kameyama, Mitsuhiro Tada, Koji Nakagawa, Shoko Yoshida, Haruhiko Kashiwazaki, Yutaka Yamazaki, Yukiko Suzuki, Akira Sasaki, Hitoshi Nagatsuka, Nobuo Inoue, Tetsuya Moriuchi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Phosphatase of regenerating liver (PRL) belongs to a class of the protein tyrosine phosphatase family, which is known so far to consist of 3 members, PRL-1, PRL-2, and PRL-3. The aim of this study was to uncover the role of PRL genes in development of oral malignancy. We analyzed expression levels of the 3 PRL genes in 50 human oral squamous cell carcinomas (OSCCs), 11 dysplasia and 12 normal mucosa tissues by a real-time RTPCR method. PRL-3 but not PRL-1 or PRL-2 expressions were significantly higher in OSCC and dysplasia than in normal mucosa tissues. Additionally, PRL-3 expressions were significantly higher in OSCC tissues harboring dominant-negative p53 or recessive p53 mutation than in those harboring wild-type p53. These results suggest that PRL-3 plays a role in oral cancer development and can be useful as a marker of pre-malignant and malignant lesion of oral mucosa.

Original languageEnglish
Pages (from-to)947-951
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume12
Issue number4
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Dysplasia
  • Oral squamous carcinoma
  • P53
  • PRL

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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  • Cite this

    Hassan, N. M. M., Hamada, J. I., Kameyama, T., Tada, M., Nakagawa, K., Yoshida, S., Kashiwazaki, H., Yamazaki, Y., Suzuki, Y., Sasaki, A., Nagatsuka, H., Inoue, N., & Moriuchi, T. (2011). Increased expression of the PRL-3 gene in human oral squamous cell carcinoma and dysplasia tissues. Asian Pacific Journal of Cancer Prevention, 12(4), 947-951.