Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain

Manabu Takaki, H. Ujike, M. Kodama, Y. Takehisa, A. Yamamoto, S. Kuroda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The rearrangement of neural networks associated with the behavioral sensitization induced by psychostimulants is poorly understood. We have investigated the effect of methamphetamine (METH) administration on the mRNA levels of three different classes of plasticity-related genes in the rat brain. The expression of synaptophysin mRNA increased 20-40% in the nucleus accumbens, prefrontal and temporal cortices, 1-24 h after acute METH administration, and that of stathmin mRNA increased about 20% in the prefrontal cortex 1 h later. They did not change after subchronic administration. The level of α-tubulin mRNA was constant. Therefore, synaptophysin and stathmin play an important role in the neural plastic changes involved in the early induction process of METH-induced sensitization, but not in the later maintenance process.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalNeuroReport
Volume12
Issue number5
Publication statusPublished - Apr 17 2001

Fingerprint

Stathmin
Synaptophysin
Methamphetamine
Messenger RNA
Brain
Prefrontal Cortex
Nucleus Accumbens
Temporal Lobe
Tubulin
Maintenance
Genes

Keywords

  • α-Tubulin
  • Behavioral sensitization
  • In situ hybridization
  • Methamphetamine
  • Neural plasticity
  • Stathmin
  • Synaptophysin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Takaki, M., Ujike, H., Kodama, M., Takehisa, Y., Yamamoto, A., & Kuroda, S. (2001). Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain. NeuroReport, 12(5), 1055-1060.

Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain. / Takaki, Manabu; Ujike, H.; Kodama, M.; Takehisa, Y.; Yamamoto, A.; Kuroda, S.

In: NeuroReport, Vol. 12, No. 5, 17.04.2001, p. 1055-1060.

Research output: Contribution to journalArticle

Takaki, M, Ujike, H, Kodama, M, Takehisa, Y, Yamamoto, A & Kuroda, S 2001, 'Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain', NeuroReport, vol. 12, no. 5, pp. 1055-1060.
Takaki M, Ujike H, Kodama M, Takehisa Y, Yamamoto A, Kuroda S. Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain. NeuroReport. 2001 Apr 17;12(5):1055-1060.
Takaki, Manabu ; Ujike, H. ; Kodama, M. ; Takehisa, Y. ; Yamamoto, A. ; Kuroda, S. / Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain. In: NeuroReport. 2001 ; Vol. 12, No. 5. pp. 1055-1060.
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