Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain

M. Takaki, H. Ujike, M. Kodama, Y. Takehisa, A. Yamamoto, S. Kuroda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The rearrangement of neural networks associated with the behavioral sensitization induced by psychostimulants is poorly understood. We have investigated the effect of methamphetamine (METH) administration on the mRNA levels of three different classes of plasticity-related genes in the rat brain. The expression of synaptophysin mRNA increased 20-40% in the nucleus accumbens, prefrontal and temporal cortices, 1-24 h after acute METH administration, and that of stathmin mRNA increased about 20% in the prefrontal cortex 1 h later. They did not change after subchronic administration. The level of α-tubulin mRNA was constant. Therefore, synaptophysin and stathmin play an important role in the neural plastic changes involved in the early induction process of METH-induced sensitization, but not in the later maintenance process.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalNeuroReport
Volume12
Issue number5
DOIs
Publication statusPublished - Apr 17 2001

Keywords

  • Behavioral sensitization
  • In situ hybridization
  • Methamphetamine
  • Neural plasticity
  • Stathmin
  • Synaptophysin
  • α-Tubulin

ASJC Scopus subject areas

  • Neuroscience(all)

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