Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas

Toyoaki Hida, Yasushi Yatabe, Hiroyuki Achiwa, Hideki Muramatsu, Ken Ichi Kozaki, Shigeo Nakamura, Makoto Ogawa, Tetsuya Mitsudomi, Takahiko Sugiura, Takashi Takahashi

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Abstract

Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59 human lung cancers as well as in normal and premalignant lung specimens. In contrast to scattered weak reactivity seen in normal peripheral airway epithelial cells, markedly up-regulated COX-2 expression was detected in about one-third of atypical adenomatous hyperplasias and carcinoma in situ specimens, and a significant increase in COX-2 expression was observed in 70% of invasive adenocarcinoma cases. Interestingly, the proportion of adenocarcinoma cells with marked COX-2 expression was much greater in lymph node metastases than in the corresponding primary tumors. In contrast, small cell carcinomas showed virtually negligible expression, and squamous cell carcinomas showed infrequent and low expression. These findings suggest that an increase in COX-2 expression may be associated with the development of adenocarcinomas and possibly with acquisition of an invasive and metastatic phenotype.

Original languageEnglish
Pages (from-to)3761-3764
Number of pages4
JournalCancer Research
Volume58
Issue number17
Publication statusPublished - Sep 1 1998

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Hida, T., Yatabe, Y., Achiwa, H., Muramatsu, H., Kozaki, K. I., Nakamura, S., Ogawa, M., Mitsudomi, T., Sugiura, T., & Takahashi, T. (1998). Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Research, 58(17), 3761-3764.