Increased eosinophilic cationic protein in nasal fluid in hospitalized wheezy infants with RSV infection

Naoko Okamoto, Masanori Ikeda, Masato Okuda, Tomoko Sakamoto, Mizue Takasugi, Nobumasa Takahashi, Toru Araki, Tsuneo Morishima, Kozo Yasui

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Respiratory syncytial virus (RSV) is a major respiratory pathogen which causes bronchiolitis with dyspnea and wheezing in children less than 2 years old. RSV bronchiolitis in infancy severe enough to cause hospitalization might be a risk factor for allergic sensitization and bronchial asthma in future. However, the pathophysiology behind this development has not been clearly characterized. To evaluate the existence of airway inflammation and characteristic of RSV bronchiolitis, we analyzed and compared the concentrations of eosinophilic cationic protein (ECP) in nasal fluid and plasma. Methods: From 69 infants (aged

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalAllergology International
Volume60
Issue number4
DOIs
Publication statusPublished - Dec 13 2011
Externally publishedYes

Fingerprint

Respiratory Syncytial Virus Infections
Bronchiolitis
Respiratory Syncytial Viruses
Nose
Proteins
Respiratory Sounds
Dyspnea
Hospitalization
Asthma
Inflammation

Keywords

  • Airway inflammation
  • Eosinophilic cationic protein
  • Eosinophils
  • Neutrophils
  • Respiratory syncitial virus

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Okamoto, N., Ikeda, M., Okuda, M., Sakamoto, T., Takasugi, M., Takahashi, N., ... Yasui, K. (2011). Increased eosinophilic cationic protein in nasal fluid in hospitalized wheezy infants with RSV infection. Allergology International, 60(4), 467-472. https://doi.org/10.2332/allergolint.10-OA-0263

Increased eosinophilic cationic protein in nasal fluid in hospitalized wheezy infants with RSV infection. / Okamoto, Naoko; Ikeda, Masanori; Okuda, Masato; Sakamoto, Tomoko; Takasugi, Mizue; Takahashi, Nobumasa; Araki, Toru; Morishima, Tsuneo; Yasui, Kozo.

In: Allergology International, Vol. 60, No. 4, 13.12.2011, p. 467-472.

Research output: Contribution to journalArticle

Okamoto, N, Ikeda, M, Okuda, M, Sakamoto, T, Takasugi, M, Takahashi, N, Araki, T, Morishima, T & Yasui, K 2011, 'Increased eosinophilic cationic protein in nasal fluid in hospitalized wheezy infants with RSV infection', Allergology International, vol. 60, no. 4, pp. 467-472. https://doi.org/10.2332/allergolint.10-OA-0263
Okamoto, Naoko ; Ikeda, Masanori ; Okuda, Masato ; Sakamoto, Tomoko ; Takasugi, Mizue ; Takahashi, Nobumasa ; Araki, Toru ; Morishima, Tsuneo ; Yasui, Kozo. / Increased eosinophilic cationic protein in nasal fluid in hospitalized wheezy infants with RSV infection. In: Allergology International. 2011 ; Vol. 60, No. 4. pp. 467-472.
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