Increased DOI-induced wet-dog shakes in adrenocorticotropic hormone-treated rats are not affected by chronic imipramine treatment: Possible involvement of enhanced 5-HT2A-receptor expression in the frontal cortex

Yoshihisa Kitamura, Kazuhiko Shibata, Kozue Akiyama, Shizue Kimoto, Yoshika Fujitani, Kouhei Kitagawa, Hirotaka Kanzaki, Mamoru Ouchida, Kenji Shimizu, Hiromu Kawasaki, Toshiaki Sendo, Yutaka Gomita

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We examined the influence of imipramine, a traditional tricyclic antidepressant, on the binding to serotonin (5-HT)2 receptors and levels of 5-HT2A-receptor mRNA in the frontal cortex of rats treated with adrenocorticotropic hormone (ACTH). Chronic treatment with ACTH significantly increased the binding of [3H]-ketanserin to 5-HT 2 receptors and the expression of 5-HT2A-receptor mRNA in the frontal cortex. However, it did not alter the concentration of 5-HT or 5-hydroxyindole acetic acid. The effect of chronic ACTH treatment on 5-HT 2 receptor and 5-HT2A-receptor mRNA levels was not altered by the chronic administration of imipramine. Also, imipramine did not affect the hyperfunction of 5-HT2A receptors caused by chronic ACTH treatment. These findings suggest that chronic treatment with ACTH acts to increase 5-HT2A-receptor synthesis through increased gene transcription, without modulating presynaptic serotonergic neurotransmission.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalJournal of Pharmacological Sciences
Volume106
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • 5-HT receptor
  • Adrenocorticotropic hormone
  • Receptor binding
  • Receptor mRNA
  • Wet-dog shake

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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