Increased concentrations of the basement membrane component type IV collagen in sera and urine of diabetics

Y. Hayashi, H. Makino, K. Shikata, T. Haramoto, Y. Yamasaki, I. Kumagai, Z. Ota

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We measured serum and urinary concentrations of type IV collagen by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in diabetics. Serum and urinary concentrations of type IV collagen measured by RIA and ELISA were increased compared to those of control subjects. In diabetics with macroproteinuria or with renal insufficiency, serum and urinary concentrations of type IV collagen were higher than in diabetics without nephropathy or with early renal damage as determined by the presence of microproteinuria. These results suggest that serum and urinary concentrations of type IV collagen are increased in patients with advanced diabetic nephropathy. These increases may indicate that alteration of basement membrane metabolism has occurred in diabetics.

Original languageEnglish
Pages (from-to)195-196
Number of pages2
JournalJournal of Diabetic Complications
Volume5
Issue number2-3
DOIs
Publication statusPublished - Jan 1 1991

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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