Increased anxiety-related behavior in mice following β-citronellol inhalation

Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara

Research output: Contribution to journalArticle

Abstract

β-Citronellol is a monoterpene alcohol found in essential oils of various aromatic plant species. The physiological effects of β-citronellol inhalation on the central nervous system remain unclear. We investigated the effects of β-citronellol inhalation on mouse behavior. First, we examined whether the odor of β-citronellol was attractive or repellent to mice. Then, following 30 minutes of β-citronellol inhalation, a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, and forced swim tests) were performed. Mice were neither attracted to nor repelled by β-citronellol. Mice that inhaled β-citronellol showed an increase in anxiety-like behavior in the elevated plus maze and open field tests. Performance in the Y-maze and forced swim tests was not affected. These results indicate that β-citronellol acts on the central nervous system of mice following inhalation and increases anxiety. Essential oils and cosmetics containing β-citronellol should be used with caution.

Original languageEnglish
Article number1767275
JournalLibyan Journal of Medicine
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Anxiogenic
  • citronellol
  • essential oil
  • inhalation
  • odor

ASJC Scopus subject areas

  • Medicine(all)

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    Ueno, H., Shimada, A., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Takahashi, Y., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2020). Increased anxiety-related behavior in mice following β-citronellol inhalation. Libyan Journal of Medicine, 15(1), [1767275]. https://doi.org/10.1080/19932820.2020.1767275