Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats

Takao Yasuhara, Koichi Hara, Kapil D. Sethi, John C. Morgan, Cesario V. Borlongan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

8-Hydroxy-2′-deoxyguanosine (8-OHdG), the predominant marker of oxidative DNA damage, may be a good biomarker for monitoring the progression of Parkinson's disease (PD). Unfortunately, there are no basic laboratory data examining 8-OHdG levels in animal models of PD. In this study, we demonstrate that rats lesioned with 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle display significantly elevated 8-OHdG levels in urine, serum, and substantia nigra, but not cerebrospinal fluid and striatum, compared to sham controls. These increments in 8-OHdG levels were detected at 2 days, but not at 7 days after the lesion suggesting that oxidative stress is restricted to the acute phase of 6-OHDA neurotoxicity. The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalBrain Research
Volume1133
Issue number1
DOIs
Publication statusPublished - Jan 16 2007
Externally publishedYes

Keywords

  • 8-OHdG
  • Biomarker
  • Neurodegeneration
  • Oxidative stress
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Increased 8-OHdG levels in the urine, serum, and substantia nigra of hemiparkinsonian rats'. Together they form a unique fingerprint.

  • Cite this