Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides

Kotaro Tada, Toshihisa Hamada, Kenji Asagoe, Hiroshi Umemura, Kazuko Mizuno-Ikeda, Yumi Aoyama, Masaki Otsuka, Osamu Yamasaki, Keiji Iwatsuki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Little is known about the immunological milieu of the skindraining lymph nodes (LNs) in mycosis fungoides (MF). Objectives: We studied dendritic cell (DC) subsets in the dermatopathic lymphadenitis of MF patients. Methods: We immunohistochemically examined DC subsets and their distribution in 16 LN samples from 14 patients with MF (N1 LN, eight patients; N2, four; and N3, four), and we compared them with non-metastatic sentinel LNs from eight patients with melanoma. Results: The number of S-100 protein+ DCs was markedly increased in the LNs from theMFpatients and the major componentwasDC-LAMP+ mature DCs in the outer and paracortex areas, where DC-SIGN+ immature DCs were relatively decreased in proportion. In contrast, DC-SIGN+ cells were relatively increased in proportion compared to DC-LAMP+ cells in the medulla. Although no significant difference was observed in the proportions of CD1a+ or Langerin+ DCs among the N1, N2, and N3 nodes, CD163+ M2-type macrophages were increased in number in the N2 and N3 nodes. Conclusions: Our observations indicate that mature DCs accumulate in the outer and paracortex areas in dermatopathic lymphadenitis and M2-type macrophages might increase in number during disease progression.

Original languageEnglish
Pages (from-to)670-675
Number of pages6
JournalEuropean Journal of Dermatology
Volume24
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Mycosis Fungoides
Lymphadenitis
Dendritic Cells
Lymph Nodes
Macrophages
S100 Proteins
Disease Progression
Melanoma

Keywords

  • DC-LAMP
  • DC-SIGN
  • Dendritic cell
  • Dermatopathic lymphadenitis
  • M2-type macrophage
  • Mycosis fungoides

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Tada, K., Hamada, T., Asagoe, K., Umemura, H., Mizuno-Ikeda, K., Aoyama, Y., ... Iwatsuki, K. (2014). Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides. European Journal of Dermatology, 24(6), 670-675. https://doi.org/10.1684/ejd.2014.2437

Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides. / Tada, Kotaro; Hamada, Toshihisa; Asagoe, Kenji; Umemura, Hiroshi; Mizuno-Ikeda, Kazuko; Aoyama, Yumi; Otsuka, Masaki; Yamasaki, Osamu; Iwatsuki, Keiji.

In: European Journal of Dermatology, Vol. 24, No. 6, 2014, p. 670-675.

Research output: Contribution to journalArticle

Tada, K, Hamada, T, Asagoe, K, Umemura, H, Mizuno-Ikeda, K, Aoyama, Y, Otsuka, M, Yamasaki, O & Iwatsuki, K 2014, 'Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides', European Journal of Dermatology, vol. 24, no. 6, pp. 670-675. https://doi.org/10.1684/ejd.2014.2437
Tada, Kotaro ; Hamada, Toshihisa ; Asagoe, Kenji ; Umemura, Hiroshi ; Mizuno-Ikeda, Kazuko ; Aoyama, Yumi ; Otsuka, Masaki ; Yamasaki, Osamu ; Iwatsuki, Keiji. / Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides. In: European Journal of Dermatology. 2014 ; Vol. 24, No. 6. pp. 670-675.
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AU - Mizuno-Ikeda, Kazuko

AU - Aoyama, Yumi

AU - Otsuka, Masaki

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AU - Iwatsuki, Keiji

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