Increase of cytochrome c oxidase negative fibers in rimmed vacuole myopathy with inflammatory changes

Koji Takahashi, Tetsuya Nishinaka, Kenichi Kashihara, Hideki Ishizu, Yasuaki Hayashi, Toshikiyo Shohmori, Koji Abe

Research output: Contribution to journalArticle

Abstract

The physiological significance of cytochrome c oxidase (CCO) deficiency in rimmed vacuole myopathy (RVM) is not fully understood. Frequencies of CCO negative muscle fibers (CCO(-)F) were compared with two cases of inclusion body myositis (IBM) and another two cases with RVM without inflammatory changes (i.e. oculopharyngeal distal myopathy (OPDM) and distal myopathy with rimmed vacuole formation (DMRV)). The frequencies of CCO(-)F were 6.9% in the case of definite IBM with 10 years of disease duration, 0.3% in possible IBM of 1 year duration, 1.3% in OPDM of 11 years duration, and 0.1% in DMRV of 2 years duration. The frequencies of CCO(-)F were generally higher in RVM than in controls. However, the incidence of CCO(-)F increased with time in patients with IBM compared with patients with RVM without inflammation. The present findings may provide important information on the myopathological distinction of IBM and RVM without inflammation.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalNeuropathology
Volume19
Issue number1
DOIs
Publication statusPublished - 1999

Fingerprint

Electron Transport Complex IV
Inclusion Body Myositis
Distal Myopathies
Cytochrome-c Oxidase Deficiency
Inflammation
Nonaka type Distal myopathy
Muscles
Incidence

Keywords

  • CCO negative muscle fibers
  • Cytochrome c oxidase
  • Inclusion body myositis
  • mtDNA deletion
  • Rimmed vacuole myopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Increase of cytochrome c oxidase negative fibers in rimmed vacuole myopathy with inflammatory changes. / Takahashi, Koji; Nishinaka, Tetsuya; Kashihara, Kenichi; Ishizu, Hideki; Hayashi, Yasuaki; Shohmori, Toshikiyo; Abe, Koji.

In: Neuropathology, Vol. 19, No. 1, 1999, p. 57-63.

Research output: Contribution to journalArticle

Takahashi, K, Nishinaka, T, Kashihara, K, Ishizu, H, Hayashi, Y, Shohmori, T & Abe, K 1999, 'Increase of cytochrome c oxidase negative fibers in rimmed vacuole myopathy with inflammatory changes', Neuropathology, vol. 19, no. 1, pp. 57-63. https://doi.org/10.1046/j.1440-1789.1999.00217.x
Takahashi, Koji ; Nishinaka, Tetsuya ; Kashihara, Kenichi ; Ishizu, Hideki ; Hayashi, Yasuaki ; Shohmori, Toshikiyo ; Abe, Koji. / Increase of cytochrome c oxidase negative fibers in rimmed vacuole myopathy with inflammatory changes. In: Neuropathology. 1999 ; Vol. 19, No. 1. pp. 57-63.
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