Incidence rate and characteristics of symptomatic vitamin d deficiency in children: A nationwide survey in Japan

Takuo Kubota, Hirofumi Nakayama, Taichi Kitaoka, Yosikazu Nakamura, Seiji Fukumoto, Ikuma Fujiwara, Yukihiro Hasegawa, Kenji Ihara, Sachiko Kitanaka, Satomi Koyama, Satoshi Kusuda, Haruo Mizuno, Keisuke Nagasaki, Koji Oba, Yuko Sakamoto, Noriyuki Takubo, Toshiaki Shimizu, Yusuke Tanahashi, Kousei Hasegawa, Hirokazu TsukaharaTohru Yorifuji, Toshimi Michigami, Keiichi Ozono

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145–222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9–1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7–4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalEndocrine Journal
Volume65
Issue number6
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Avitaminosis
Vitamin D Deficiency
Japan
Incidence
Confidence Intervals
Surveys and Questionnaires
Rickets
Hypocalcemia
Solar System
Breast Feeding
Population
Leg
Public Health
Pediatrics
Diet

Keywords

  • Children
  • Hypocalcemia
  • Nationwide survey
  • Rickets
  • Vitamin D deficiency

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kubota, T., Nakayama, H., Kitaoka, T., Nakamura, Y., Fukumoto, S., Fujiwara, I., ... Ozono, K. (2018). Incidence rate and characteristics of symptomatic vitamin d deficiency in children: A nationwide survey in Japan. Endocrine Journal, 65(6), 593-599. https://doi.org/10.1507/endocrj.EJ18-0008

Incidence rate and characteristics of symptomatic vitamin d deficiency in children : A nationwide survey in Japan. / Kubota, Takuo; Nakayama, Hirofumi; Kitaoka, Taichi; Nakamura, Yosikazu; Fukumoto, Seiji; Fujiwara, Ikuma; Hasegawa, Yukihiro; Ihara, Kenji; Kitanaka, Sachiko; Koyama, Satomi; Kusuda, Satoshi; Mizuno, Haruo; Nagasaki, Keisuke; Oba, Koji; Sakamoto, Yuko; Takubo, Noriyuki; Shimizu, Toshiaki; Tanahashi, Yusuke; Hasegawa, Kousei; Tsukahara, Hirokazu; Yorifuji, Tohru; Michigami, Toshimi; Ozono, Keiichi.

In: Endocrine Journal, Vol. 65, No. 6, 01.01.2018, p. 593-599.

Research output: Contribution to journalArticle

Kubota, T, Nakayama, H, Kitaoka, T, Nakamura, Y, Fukumoto, S, Fujiwara, I, Hasegawa, Y, Ihara, K, Kitanaka, S, Koyama, S, Kusuda, S, Mizuno, H, Nagasaki, K, Oba, K, Sakamoto, Y, Takubo, N, Shimizu, T, Tanahashi, Y, Hasegawa, K, Tsukahara, H, Yorifuji, T, Michigami, T & Ozono, K 2018, 'Incidence rate and characteristics of symptomatic vitamin d deficiency in children: A nationwide survey in Japan', Endocrine Journal, vol. 65, no. 6, pp. 593-599. https://doi.org/10.1507/endocrj.EJ18-0008
Kubota, Takuo ; Nakayama, Hirofumi ; Kitaoka, Taichi ; Nakamura, Yosikazu ; Fukumoto, Seiji ; Fujiwara, Ikuma ; Hasegawa, Yukihiro ; Ihara, Kenji ; Kitanaka, Sachiko ; Koyama, Satomi ; Kusuda, Satoshi ; Mizuno, Haruo ; Nagasaki, Keisuke ; Oba, Koji ; Sakamoto, Yuko ; Takubo, Noriyuki ; Shimizu, Toshiaki ; Tanahashi, Yusuke ; Hasegawa, Kousei ; Tsukahara, Hirokazu ; Yorifuji, Tohru ; Michigami, Toshimi ; Ozono, Keiichi. / Incidence rate and characteristics of symptomatic vitamin d deficiency in children : A nationwide survey in Japan. In: Endocrine Journal. 2018 ; Vol. 65, No. 6. pp. 593-599.
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