Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children

Hirotoshi Sakaguchi, Yoshiyuki Takahashi, Nobuhiro Watanabe, Sayoko Doisaki, Hideki Muramatsu, Asahito Hama, Akira Shimada, Hiroshi Yagasaki, Kazuko Kudo, Seiji Kojima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Idiopathic pneumonia syndrome (IPS) is a severe complication that can occur after hematopoietic stem cell transplantation (HSCT) and is often associated with a fatal outcome despite intensive supportive care. Procedure: To assess the incidence and risk factors of IPS, we reviewed 251 consecutive patients (median age, 7.0 years) who received HSCT at the Department of Pediatrics, Nagoya University Hospital, between January 1990 and July 2009. Results: Twenty of 251 (cumulative incidence of IPS at 2 years after HSCT, 8.0%; 95% confidence interval (CI), 5.1-12.4%) patients developed IPS. The median duration from HSCT to diagnosis of IPS was 67 days (range, 12-486 days). Patients with IPS had significantly higher 5-year transplant-related mortality compared to patients without IPS (52% (95% CI, 19-77%) vs. 13% (95% CI, 5-25%), P

Original languageEnglish
Pages (from-to)780-784
Number of pages5
JournalPediatric Blood and Cancer
Volume58
Issue number5
DOIs
Publication statusPublished - May 2012
Externally publishedYes

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Hematopoietic Stem Cell Transplantation
Pneumonia
Incidence
Confidence Intervals
Fatal Outcome
Critical Care
Pediatrics
Transplants
Mortality

Keywords

  • Busulfan
  • Complication
  • Idiopathic pneumonia syndrome
  • Pediatrics
  • Stem cell transplantation

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children. / Sakaguchi, Hirotoshi; Takahashi, Yoshiyuki; Watanabe, Nobuhiro; Doisaki, Sayoko; Muramatsu, Hideki; Hama, Asahito; Shimada, Akira; Yagasaki, Hiroshi; Kudo, Kazuko; Kojima, Seiji.

In: Pediatric Blood and Cancer, Vol. 58, No. 5, 05.2012, p. 780-784.

Research output: Contribution to journalArticle

Sakaguchi, H, Takahashi, Y, Watanabe, N, Doisaki, S, Muramatsu, H, Hama, A, Shimada, A, Yagasaki, H, Kudo, K & Kojima, S 2012, 'Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children', Pediatric Blood and Cancer, vol. 58, no. 5, pp. 780-784. https://doi.org/10.1002/pbc.23298
Sakaguchi, Hirotoshi ; Takahashi, Yoshiyuki ; Watanabe, Nobuhiro ; Doisaki, Sayoko ; Muramatsu, Hideki ; Hama, Asahito ; Shimada, Akira ; Yagasaki, Hiroshi ; Kudo, Kazuko ; Kojima, Seiji. / Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children. In: Pediatric Blood and Cancer. 2012 ; Vol. 58, No. 5. pp. 780-784.
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