Inadequate increase in the volume of major epicardial coronary arteries compared with that in left ventricular mass - Novel concept for characterization of coronary arteries using 64-slice computed tomography

Shoichi Ehara, Takuhiro Okuyama, Nobuyuki Shirai, Kenichi Sugioka, Hiroki Oe, Toshihide Itoht, Toshiyuki Matsuoka, Yoshihiro Ikura, Makiko Ueda, Takahiko Naruko, Takeshi Hozumi, Minoru Yoshiyama

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Background: Previous studies have shown a correlation between coronary artery cross-sectional diameter and left ventricular (LV) mass. However, no studies have examined the correlation between actual coronary artery volume (CAV) and LV mass. In the present study, measurements of CAV by 64-multislice computed tomography (MSCT) were validated and the relationship between CAV and LV mass was investigated. Methods and Results: First, coronary artery phantoms consisting of syringes filled with solutions of contrast medium moving at simulated heart rates were scanned by 64-MSCT. Display window settings permitting accurate calculation of small volumes were optimized by evaluating volume-rendered images of the segmented contrast medium at different window settings. Next, 61 patients without significant coronary artery stenosis were scanned by 64-MSCT with the same protocol as for the phantoms. Coronary arteries were segmented on a workstation and the same window settings were applied to the volume-rendered images to calculate total CAV. Significant correlations between total CAV and LV mass (r=0.660, P<0.0001) were found, whereas an inverse relation was present between total CAV per 100 g of LV mass and LV mass. Conclusions: The novel concept of "CAV" for the characterization of coronary arteries may prove useful for future research, particularly on the causes of LV hypertrophy.

Original languageEnglish
Pages (from-to)1448-1453
Number of pages6
JournalCirculation Journal
Issue number8
Publication statusPublished - Aug 1 2009



  • Computed tomography
  • Coronary artery
  • Hypertrophy
  • Left ventricular mass

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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