TY - JOUR
T1 - In Vivo Microwave Ablation of Normal Swine Lung at High-power, Short-duration Settings
AU - Iguchi, Toshihiro
AU - Hiraki, Takao
AU - Matsui, Yusuke
AU - Toji, Tomohiro
AU - Uka, Mayu
AU - Tomita, Koji
AU - Komaki, Toshiyuki
AU - Umakoshi, Noriyuki
AU - Mitsuhashi, Toshiharu
AU - Kanazawa, Susumu
N1 - Funding Information:
Acknowledgments. This work was supported by JSPS KAKENHI Grant Number JP19K08227.
Publisher Copyright:
© 2022 by Okayama University Medical School.
PY - 2022
Y1 - 2022
N2 - To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2 or 3-min ablation. There were no significant differences between the 2 and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neigh-boring bronchus might occur.
AB - To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2 or 3-min ablation. There were no significant differences between the 2 and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neigh-boring bronchus might occur.
KW - Ablation zone
KW - Heat-sink effect
KW - Lung
KW - Microwave ablation
KW - Swine
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U2 - 10.18926/AMO/63212
DO - 10.18926/AMO/63212
M3 - Article
C2 - 35236999
AN - SCOPUS:85125611922
VL - 76
SP - 57
EP - 62
JO - Acta Medica Okayama
JF - Acta Medica Okayama
SN - 0386-300X
IS - 1
ER -