In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat

Yuichiro Minamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Kiyoshi Hosokawa, Yasushi Okada, Tetuhide H. Murakami, Tetsuro Negi, Osamu Hatase

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83 Citations (Scopus)

Abstract

Extracellular concentrations of γ-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalBrain Research
Volume573
Issue number2
DOIs
Publication statusPublished - Feb 28 1992

Keywords

  • Aspartate
  • Epilepsy
  • Glutamate
  • Kindling
  • Microdialysis
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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  • Cite this

    Minamoto, Y., Itano, T., Tokuda, M., Matsui, H., Janjua, N. A., Hosokawa, K., Okada, Y., Murakami, T. H., Negi, T., & Hatase, O. (1992). In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat. Brain Research, 573(2), 345-348. https://doi.org/10.1016/0006-8993(92)90786-9