Abstract
We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 291-296 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 833 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 3 1999 |
| Externally published | Yes |
Keywords
- Hippocampus
- Microdialysis
- Rat
- Serotonin
- Sleep
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
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Cite this
Park, S. P., Lopez-Rodriguez, F., Wilson, C. L., Maidment, N., Matsumoto, Y., & Engel, J. (1999). In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness. Brain Research, 833(2), 291-296. https://doi.org/10.1016/S0006-8993(99)01511-5