In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness

Sung Pa Park; Faustino Lopez-Rodriguez; Charles L. Wilson; Nigel Maidment; Yosuke Matsumoto; Jerome Engel

doi:10.1016/S0006-8993(99)01511-5

In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness

Sung Pa Park, Faustino Lopez-Rodriguez, Charles L. Wilson, Nigel Maidment, Yosuke Matsumoto, Jerome Engel

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.

Original language	English
Pages (from-to)	291-296
Number of pages	6
Journal	Brain Research
Volume	833
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)01511-5
Publication status	Published - Jul 3 1999
Externally published	Yes

Keywords

Hippocampus
Microdialysis
Rat
Serotonin
Sleep

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness",

abstract = "We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.",

keywords = "Hippocampus, Microdialysis, Rat, Serotonin, Sleep",

author = "Park, {Sung Pa} and Faustino Lopez-Rodriguez and Wilson, {Charles L.} and Nigel Maidment and Yosuke Matsumoto and Jerome Engel",

note = "Funding Information: We wish to thank Joyel Almajano for technical assistance, Toan Do and Larry Ackerson for HPLC analysis, and Tony Fields for EEG recording assistance. Faustino Lopez-Rodriguez was supported by a Program in Minority Research Training in Psychiatry Fellowship, funded by NIMH, MH 19126. Funding was provided by NIH grants NS 33310 and NS 02808. ",

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AU - Park, Sung Pa

AU - Lopez-Rodriguez, Faustino

AU - Wilson, Charles L.

AU - Maidment, Nigel

AU - Matsumoto, Yosuke

AU - Engel, Jerome

N1 - Funding Information: We wish to thank Joyel Almajano for technical assistance, Toan Do and Larry Ackerson for HPLC analysis, and Tony Fields for EEG recording assistance. Faustino Lopez-Rodriguez was supported by a Program in Minority Research Training in Psychiatry Fellowship, funded by NIMH, MH 19126. Funding was provided by NIH grants NS 33310 and NS 02808.

PY - 1999/7/3

Y1 - 1999/7/3

N2 - We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.

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KW - Hippocampus

KW - Microdialysis

KW - Rat

KW - Serotonin

KW - Sleep

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