In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness

Sung Pa Park, Faustino Lopez-Rodriguez, Charles L. Wilson, Nigel Maidment, Yosuke Matsumoto, Jerome Engel

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalBrain Research
Volume833
Issue number2
DOIs
Publication statusPublished - Jul 3 1999
Externally publishedYes

Keywords

  • Hippocampus
  • Microdialysis
  • Rat
  • Serotonin
  • Sleep

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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