In vivo evaluation of hydroxyapatite nanocoating on polyester artificial vascular grafts and possibility as soft-tissue compatible material

Hiroyuki Kadono, Tsutomu Furuzono, Miwa Masuda, Masahiro Okada, Mitsuki Ueki, Keiichi Takamizawa, Ryoichi Tanaka, Kunio Miyatake, Yoshihisa Koyama, Kazuo Takakuda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The efficacy of hydroxyapatite (HAp) nanocoating on polyester vascular grafts was investigated in animal experiments. The HAp nanocrystals were covalently bonded separately between hydroxyl groups on a nanocrystal and alkoxysilyl groups in γ-methacryloxypropyl triethoxysilane graft polymerized on a polyester substrate. Twelve HAp-coated polyester grafts and 10 control grafts of 20, 30, or 50 mm in length were implanted in canine common carotid arteries. Serious complications or occlusions were not observed in any of the dogs after implantation. A histologic evaluation was conducted by staining with hematoxylin and eosin (HE), the von Willebrand factor (vWf), and α-smooth muscle actin (α-SMA) around the inner lumen of the grafts. The number of inflammation cells and giant cells in the HAp-coated group was significantly lower than that in the group receiving noncoated grafts (p < 0.05).

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalASAIO Journal
Volume56
Issue number1
DOIs
Publication statusPublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Kadono, H., Furuzono, T., Masuda, M., Okada, M., Ueki, M., Takamizawa, K., Tanaka, R., Miyatake, K., Koyama, Y., & Takakuda, K. (2010). In vivo evaluation of hydroxyapatite nanocoating on polyester artificial vascular grafts and possibility as soft-tissue compatible material. ASAIO Journal, 56(1), 61-66. https://doi.org/10.1097/MAT.0b013e3181c945ae