In vivo evaluation of chelate-Setting cement fabricated from hydroxyapatite including bone minerals using a rabbit's tibia model

Mamoru Aizawa, Yuki Chibu, Kohei Nagata, Toshiisa Konishi, Ken Ishii, Haruki Funao, Yoshiaki Toyama, Morio Matsumoto, Michiyo Honda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hydroxyapatite (HAp) is one of components of bone and teeth, and has an osteoconductivity. Thus, the HAp has been used as biomaterials for bone graftings. We have succeeded in development of the novel chelate-setting calcium-phosphate cement (CPC) using pure HAp particles surface-modified with inositol phosphate (IP6). While, biological apatite presented in bone and teeth of mammals contains various ions: Na+, K+, Mg2+, C1-", F" and C032-", in addition to Ca2+ and P04 ions. In this work, in order to create the chelate-setting CPC with enhanced osteoconductivity, the above-mentioned biological apatite powder (hereafter, bone HAp), instead of pure HAp, was used as a starting powder for fabrication of the chelate-setting cement. The biocompatibility of the resulting chelate-setting bone HAp cement (hereafter, IP6-bone HAp cement) was examined using a rabbit's tibia model. When the living reaction to hard tissue was histologically examined after 4 weeks implantation, we could observe that newly-formed bone directly bonded to the surface of the specimen. The newly-formed bone was also present around the cement specimen. The amounts of newly-formed bone around IP6-bone HAp cement was about 1.5 times those around IP6-pure HAp cement without bone minerals. The above findings demonstrate that the present IP6-bone HAp cements are one of the promising candidates as novel CPC with enhanced osteoconductivity.

Original languageEnglish
Title of host publicationBioceramics 26
EditorsMaria-Pau Ginebra, Cristina Canal, Montserrat Espanol, Edgar B. Montufar, Roman A. Perez
PublisherTrans Tech Publications Ltd
Pages402-407
Number of pages6
ISBN (Electronic)9783038352822
DOIs
Publication statusPublished - Jan 1 2015
Event26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014 - Barcelona, Spain
Duration: Nov 6 2014Nov 8 2014

Publication series

NameKey Engineering Materials
Volume631
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2014
CountrySpain
CityBarcelona
Period11/6/1411/8/14

Keywords

  • Bone minerals
  • Calcium-phosphate cement
  • Chelate-setting cement
  • Hydroxyapatite
  • In vivo evaluation
  • Inositol phosphate

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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    Aizawa, M., Chibu, Y., Nagata, K., Konishi, T., Ishii, K., Funao, H., Toyama, Y., Matsumoto, M., & Honda, M. (2015). In vivo evaluation of chelate-Setting cement fabricated from hydroxyapatite including bone minerals using a rabbit's tibia model. In M-P. Ginebra, C. Canal, M. Espanol, E. B. Montufar, & R. A. Perez (Eds.), Bioceramics 26 (pp. 402-407). (Key Engineering Materials; Vol. 631). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net.KEM.631.402