In vivo effect of fluoride-substituted apatite on rat bone

Miho Inoue, Hitoshi Nagatsuka, Hidetsugu Tsujigiwa, Masahisa Inoue, Racquel Z. LeGeros, Toshio Yamamoto, Noriyuki Nagai

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Different types of calcium phosphate compounds are commercially available for medical and dental applications as bone substitute materials. Biological apatites contain several kinds of minor elements such as carbonate (CO 3), magnesium (Mg), and fluoride (F) in enamel, dentin, and bone. It has been shown that F ion and F-substituted apatite promoted osteoblast proliferation and inhibited osteoclast cell activity. The purpose of this study was to investigate the in vivo rat tibia activity on F-substituted apatite (FAp). Apatites of unsintered calcium deficient apatite (CDA), and FAps, with low, medium, and high F concentrations, were implanted in rat tibia for 1 and 2 weeks. Implanted tissues were embedded in paraffin blocks, stained with hematoxylin-eosin and histomorphometrically observed. Results showed that low F concentration induced better and faster new bone formation in vivo compared to CDA. Therefore the results suggested that F as a minor element in bone rendered a suitable effect on bone formation in vivo.

Original languageEnglish
Pages (from-to)398-402
Number of pages5
JournalDental Materials Journal
Volume24
Issue number3
Publication statusPublished - Sep 2005

Fingerprint

Apatites
Apatite
Fluorides
Rats
Bone
Bone and Bones
Tibia
Osteogenesis
Calcium
Bone Substitutes
Enamels
Carbonates
Osteoblasts
Calcium phosphate
Osteoclasts
Dentin
Hematoxylin
Carbon Monoxide
Eosine Yellowish-(YS)
Dental Enamel

Keywords

  • Calcium deficient apatite
  • Fluoride substituted apatite
  • Rat tibia

ASJC Scopus subject areas

  • Dentistry(all)
  • Biomaterials

Cite this

Inoue, M., Nagatsuka, H., Tsujigiwa, H., Inoue, M., LeGeros, R. Z., Yamamoto, T., & Nagai, N. (2005). In vivo effect of fluoride-substituted apatite on rat bone. Dental Materials Journal, 24(3), 398-402.

In vivo effect of fluoride-substituted apatite on rat bone. / Inoue, Miho; Nagatsuka, Hitoshi; Tsujigiwa, Hidetsugu; Inoue, Masahisa; LeGeros, Racquel Z.; Yamamoto, Toshio; Nagai, Noriyuki.

In: Dental Materials Journal, Vol. 24, No. 3, 09.2005, p. 398-402.

Research output: Contribution to journalArticle

Inoue, M, Nagatsuka, H, Tsujigiwa, H, Inoue, M, LeGeros, RZ, Yamamoto, T & Nagai, N 2005, 'In vivo effect of fluoride-substituted apatite on rat bone', Dental Materials Journal, vol. 24, no. 3, pp. 398-402.
Inoue M, Nagatsuka H, Tsujigiwa H, Inoue M, LeGeros RZ, Yamamoto T et al. In vivo effect of fluoride-substituted apatite on rat bone. Dental Materials Journal. 2005 Sep;24(3):398-402.
Inoue, Miho ; Nagatsuka, Hitoshi ; Tsujigiwa, Hidetsugu ; Inoue, Masahisa ; LeGeros, Racquel Z. ; Yamamoto, Toshio ; Nagai, Noriyuki. / In vivo effect of fluoride-substituted apatite on rat bone. In: Dental Materials Journal. 2005 ; Vol. 24, No. 3. pp. 398-402.
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