In vivo characteristics of a transplantable Marek's disease lymphoblastoid cell line, MDCC-MSB1-41C.

H. Matsuda, J. Okamoto, Y. Sekiya, M. Yamada, F. Uno, M. Murata, S. Nii

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A Marek's disease (MD) lymphoblastoid cell line, MDCC-MSB1-41C, was highly transplantable and lethal for chickens. Autopsies showed extensive metastasis in various organs. The transplantabilities of the parent cell line, MDCC-MSB1, and another derivative line, MDCC-MSB1-33C, were transient. MD virus (MDV) could be isolated from the kidneys but not from the peripheral blood leukocytes of chickens inoculated with the MSB1-41C cell line. In addition, anti-MDV antibodies were produced both in chickens inoculated with this cell line and in controls raised with inoculated chickens, but several attempts to isolate MDV from this cell line in vitro failed.

Original languageEnglish
Pages (from-to)992-1001
Number of pages10
JournalAvian diseases
Volume27
Issue number4
DOIs
Publication statusPublished - Jan 1 1983
Externally publishedYes

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Immunology and Microbiology(all)

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