In vivo characteristics of a transplantable Marek's disease lymphoblastoid cell line, MDCC-MSB1-41C.

H. Matsuda, J. Okamoto, Y. Sekiya, Masao Yamada, F. Uno, M. Murata, S. Nii

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A Marek's disease (MD) lymphoblastoid cell line, MDCC-MSB1-41C, was highly transplantable and lethal for chickens. Autopsies showed extensive metastasis in various organs. The transplantabilities of the parent cell line, MDCC-MSB1, and another derivative line, MDCC-MSB1-33C, were transient. MD virus (MDV) could be isolated from the kidneys but not from the peripheral blood leukocytes of chickens inoculated with the MSB1-41C cell line. In addition, anti-MDV antibodies were produced both in chickens inoculated with this cell line and in controls raised with inoculated chickens, but several attempts to isolate MDV from this cell line in vitro failed.

Original languageEnglish
Pages (from-to)992-1001
Number of pages10
JournalAvian Diseases
Volume27
Issue number4
Publication statusPublished - Oct 1983
Externally publishedYes

Fingerprint

Marek Disease
Marek disease
cell lines
Chickens
Cell Line
chickens
Viruses
Mardivirus
viruses
metastasis
Autopsy
necropsy
leukocytes
Leukocytes
kidneys
Neoplasm Metastasis
Kidney
antibodies
Antibodies
blood

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • veterinary(all)

Cite this

Matsuda, H., Okamoto, J., Sekiya, Y., Yamada, M., Uno, F., Murata, M., & Nii, S. (1983). In vivo characteristics of a transplantable Marek's disease lymphoblastoid cell line, MDCC-MSB1-41C. Avian Diseases, 27(4), 992-1001.

In vivo characteristics of a transplantable Marek's disease lymphoblastoid cell line, MDCC-MSB1-41C. / Matsuda, H.; Okamoto, J.; Sekiya, Y.; Yamada, Masao; Uno, F.; Murata, M.; Nii, S.

In: Avian Diseases, Vol. 27, No. 4, 10.1983, p. 992-1001.

Research output: Contribution to journalArticle

Matsuda, H, Okamoto, J, Sekiya, Y, Yamada, M, Uno, F, Murata, M & Nii, S 1983, 'In vivo characteristics of a transplantable Marek's disease lymphoblastoid cell line, MDCC-MSB1-41C.', Avian Diseases, vol. 27, no. 4, pp. 992-1001.
Matsuda, H. ; Okamoto, J. ; Sekiya, Y. ; Yamada, Masao ; Uno, F. ; Murata, M. ; Nii, S. / In vivo characteristics of a transplantable Marek's disease lymphoblastoid cell line, MDCC-MSB1-41C. In: Avian Diseases. 1983 ; Vol. 27, No. 4. pp. 992-1001.
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