In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

Hidekazu Ishimoto, Mari Shibata, Yuki Myojin, Hideyuki Ito, Yukio Sugimoto, Akihiro Tai, Tsutomu Hatano

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.

Original languageEnglish
Pages (from-to)5901-5904
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number19
DOIs
Publication statusPublished - Oct 1 2011

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Metabolites
Anti-Inflammatory Agents
Antioxidants
Plasmas
Oral Administration
Reactive Oxygen Species
Edema
Hydrolyzable Tannins
Punicaceae
Carrageenan
Rats
3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
ellagitannin

Keywords

  • Anti-inflammatory activity
  • Antioxidant activity
  • Ellagitannin
  • Urolithin A

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. / Ishimoto, Hidekazu; Shibata, Mari; Myojin, Yuki; Ito, Hideyuki; Sugimoto, Yukio; Tai, Akihiro; Hatano, Tsutomu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 19, 01.10.2011, p. 5901-5904.

Research output: Contribution to journalArticle

Ishimoto, Hidekazu ; Shibata, Mari ; Myojin, Yuki ; Ito, Hideyuki ; Sugimoto, Yukio ; Tai, Akihiro ; Hatano, Tsutomu. / In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. In: Bioorganic and Medicinal Chemistry Letters. 2011 ; Vol. 21, No. 19. pp. 5901-5904.
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