Abstract
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Expert Opinion on Drug Discovery |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
| Externally published | Yes |
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Keywords
- 3D
- Angiogenesis
- Breast
- Cancer
- Esophagusoncology
- Organotypic
- Skin
- Spheroid
- Therapy
- Tissue engineering
ASJC Scopus subject areas
- Drug Discovery
Cite this
In vitro three-dimensional tumor microenvironment models for anticancer drug discovery. / Smalley, Keiran S M; Lioni, Mercedes; Noma, Kazuhiro; Haass, Nikolas K.; Herlyn, Meenhard.
In: Expert Opinion on Drug Discovery, Vol. 3, No. 1, 01.2008, p. 1-10.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro three-dimensional tumor microenvironment models for anticancer drug discovery
AU - Smalley, Keiran S M
AU - Lioni, Mercedes
AU - Noma, Kazuhiro
AU - Haass, Nikolas K.
AU - Herlyn, Meenhard
PY - 2008/1
Y1 - 2008/1
N2 - Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
AB - Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
KW - 3D
KW - Angiogenesis
KW - Breast
KW - Cancer
KW - Esophagusoncology
KW - Organotypic
KW - Skin
KW - Spheroid
KW - Therapy
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=38849182724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38849182724&partnerID=8YFLogxK
U2 - 10.1517/17460441.3.1.1
DO - 10.1517/17460441.3.1.1
M3 - Article
C2 - 23480136
AN - SCOPUS:38849182724
VL - 3
SP - 1
EP - 10
JO - Expert Opinion on Drug Discovery
JF - Expert Opinion on Drug Discovery
SN - 1746-0441
IS - 1
ER -