In vitro three-dimensional tumor microenvironment models for anticancer drug discovery

Keiran S M Smalley, Mercedes Lioni, Kazuhiro Noma, Nikolas K. Haass, Meenhard Herlyn

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalExpert Opinion on Drug Discovery
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Fingerprint

Tumor Microenvironment
Drug Discovery
Neoplasms
Cell Culture Techniques
In Vitro Techniques
Therapeutics

Keywords

  • 3D
  • Angiogenesis
  • Breast
  • Cancer
  • Esophagusoncology
  • Organotypic
  • Skin
  • Spheroid
  • Therapy
  • Tissue engineering

ASJC Scopus subject areas

  • Drug Discovery

Cite this

In vitro three-dimensional tumor microenvironment models for anticancer drug discovery. / Smalley, Keiran S M; Lioni, Mercedes; Noma, Kazuhiro; Haass, Nikolas K.; Herlyn, Meenhard.

In: Expert Opinion on Drug Discovery, Vol. 3, No. 1, 01.2008, p. 1-10.

Research output: Contribution to journalArticle

Smalley, Keiran S M ; Lioni, Mercedes ; Noma, Kazuhiro ; Haass, Nikolas K. ; Herlyn, Meenhard. / In vitro three-dimensional tumor microenvironment models for anticancer drug discovery. In: Expert Opinion on Drug Discovery. 2008 ; Vol. 3, No. 1. pp. 1-10.
@article{f49da71fbf2145dd9e303a505ab2377c,
title = "In vitro three-dimensional tumor microenvironment models for anticancer drug discovery",
abstract = "Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.",
keywords = "3D, Angiogenesis, Breast, Cancer, Esophagusoncology, Organotypic, Skin, Spheroid, Therapy, Tissue engineering",
author = "Smalley, {Keiran S M} and Mercedes Lioni and Kazuhiro Noma and Haass, {Nikolas K.} and Meenhard Herlyn",
year = "2008",
month = "1",
doi = "10.1517/17460441.3.1.1",
language = "English",
volume = "3",
pages = "1--10",
journal = "Expert Opinion on Drug Discovery",
issn = "1746-0441",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - In vitro three-dimensional tumor microenvironment models for anticancer drug discovery

AU - Smalley, Keiran S M

AU - Lioni, Mercedes

AU - Noma, Kazuhiro

AU - Haass, Nikolas K.

AU - Herlyn, Meenhard

PY - 2008/1

Y1 - 2008/1

N2 - Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.

AB - Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.

KW - 3D

KW - Angiogenesis

KW - Breast

KW - Cancer

KW - Esophagusoncology

KW - Organotypic

KW - Skin

KW - Spheroid

KW - Therapy

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=38849182724&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38849182724&partnerID=8YFLogxK

U2 - 10.1517/17460441.3.1.1

DO - 10.1517/17460441.3.1.1

M3 - Article

C2 - 23480136

AN - SCOPUS:38849182724

VL - 3

SP - 1

EP - 10

JO - Expert Opinion on Drug Discovery

JF - Expert Opinion on Drug Discovery

SN - 1746-0441

IS - 1

ER -