Abstract
Anticancer drug discovery has long been hampered by the poor predictivity of the preclinical models. There is a growing realization that the tumor microenvironment is a critical determinant of the response of cancer cells to therapeutic agents. The past 5 years have seen a great deal of progress in our understanding of how the three-dimensional microenvironment modulates the signaling behavior of tumor cells. The present review discusses how three-dimensional in vitro cell culture models can benefit cancer drug discovery through an accurate modeling of the tumor microenvironment, leading to more physiologically relevant experimental outcomes.
Original language | English |
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Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Expert Opinion on Drug Discovery |
Volume | 3 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2008 |
Externally published | Yes |
Keywords
- 3D
- Angiogenesis
- Breast
- Cancer
- Esophagusoncology
- Organotypic
- Skin
- Spheroid
- Therapy
- Tissue engineering
ASJC Scopus subject areas
- Drug Discovery