In vitro susceptibilites to levofloxacin and various antibacterial agents of 18,639 clinical isolates obtained from 77 centers in 2004

Keizo Yamaguchi, Akira Ohno, Yoshikazu Ishii, Kazuhiro Tateda, Morihiro Iwata, Makoto Kanda, Yoshiko Tsujio, Hiroya Kimoto, Masaharu Nishimura, Koji Akizawa, Keiko Matsuda, Tasuku Hayashi, Makoto Tominaga, Takuo Nakagawa, Shunkoh Toyoshima, Akihiro Sugita, Tatsumi Ito, Akira Suwabe, Kumiko Yamahata, Mitsuomi KaimoriToshihiko Nakamura, Chizuko Kawamura, Yosei Katayama, Minoru Yasujima, Takeshi Kasai, Masahiko Kimura, Makoto Miki, Susumu Nakanowatari, Mitsuo Kaku, Keiji Kanemitsu, Hiroyuki Kunishima, Masanori Sakurai, Joji Shiotani, Jun Okada, Akiko Yoneyama, Kazunari Kumasaka, Kazuhiko Koike, Hidenori Kominami, Toshiyuki Yamada, Toyoko Oguri, Kiyoaki Watanabe, Yoshio Kobayashi, Teruko Ohtake, Kyoichi Totsuka, Hideyuki Okamoto, Kenichiro Yamazaki, Motoi Okada, Hiromi Ikari, Naomi Kurosawa, Mori Mikio, Ichino Kano, Eiko Nagano, Harushige Kanno, Masanori Aihara, Shighefumi Maesaki, Giichi Hashikita, Eiji Miyajima, Midori Sumitomo, Nobuo Yamane, Tamio Ieiri, Kouichi Itoh, Takashi Uchida, Masami Murakami, Sachie Yomoda, Ayako Takahashi, Kazuhisa Inuzuka, Hideo Gonda, Takanori Yamashita, Ikuo Yamaguchi, Yoshinori Fujimoto, Shiomi Ishigo, Yuko Asano, Fumio Kageyama, Etsuko Shaku, Hitoshi Gemma, Keiichi Uemura, Toshinobu Horii, Hitoshi Yoshimura, Minoru Hiraoka, Hideo Wada, Hisashi Baba, Satoshi Ichiyama, Shinichi Fujita, Hidetoshi Okabe, Kenichi Tatewaki, Kunihiko Moro, Haruyoshi Yoshida, Masanobu Yamashita, Takeshi Fushiwaki, Akira Shimizu, Takayuki Takubo, Tadashi Kusakabe, Hakuo Takahashi, Hitoshi Heijyou, Koji Asai, Kunimitsu Kawahara, Reiko Sano, Syuji Matsuo, Masaru Komatsu, Yosuke Yuzuki, Norio Ikeda, Masayuki Soma, Tsuyoshi Yamamoto, Syohiro Kinosita, Seiji Kawano, Takeshi Kageoka, Toshiharu Kongo, Mikio Oka, Yoshihito Niki, Nobuchika Kusano, Eiichiro Mihara, Motoko Nose, Masao Kuwabara, Yoshihiro Fujiue, Yuji Hinoda, Nobuaki Tanaka, Toshiro Okazaki, Junichi Masuda, Tomohiko Taminato, Kiyoshi Negayama, Tetsuro Sugiura, Mitsuharu Murase, Nobuhisa Yamane, Isao Nakasone, Hisamichi Aizawa, Junichi Honda, Akihiko Okayama, Yosuke Aoki, Hiroaki Miyanohara, Kazufumi Hiramatsu, Yoichi Hirakata, Shigeru Kohno, Naotaka Hamazaki, Junko Ono, Kaoru Okada

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A total of 18,639 clinical isolates in 19 species collected from 77 centers during 2004 in Japan were tested for their susceptibility to fluoroquinolones (FQs) and other selected antibiotics. The common respiratory pathogens, Streptococcus pyogenes, Streptococcus pneumoniae, Moraxella catarrhalis and Haemophilus influenzae showed a high susceptible rate against FQs. The isolation rate of beta lactamase non-producing ampicillin-resistant H. influenzae was approximately three times as large as those of western countries. Most strains of Enterobacteriaceae were also susceptible to FQs. The resistance rate of Escherichia coli against FQs has however been rapidly increasing so far as we surveyed since 1994. The FQs-resistant rate in methicillin-resistant Staphylococcus aureus (MRSA) showed approximately 90% except for 36% of sitafloxacin while FQs-resistant rate in methicillin-susceptible S. aureus (MSSA) was around 5%. The FQs-resistant rate of methicillin-resistant coagulase negative Staphylococci (MRCNS) was also higher than that of methicillin- susceptible coagulase negative Staphylococci (MSCNS), however, it was lower than that of MRSA. In Pseudomonas aeruginosa clinical isolates, 32-34% from UTI and 15-19% of from RTI was resistant to FQs. Acinetobacter spp. showed a high susceptibility to FQs. Although FQs-resistant Neisseria gonorrhoeae have not been increased in western countries, it is remarkably high in Japan. In this survey, isolates of approximately 85% was resistant to FQs.

Original languageEnglish
Pages (from-to)428-451
Number of pages24
JournalJapanese Journal of Antibiotics
Volume59
Issue number6
Publication statusPublished - Dec 2006

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Yamaguchi, K., Ohno, A., Ishii, Y., Tateda, K., Iwata, M., Kanda, M., Tsujio, Y., Kimoto, H., Nishimura, M., Akizawa, K., Matsuda, K., Hayashi, T., Tominaga, M., Nakagawa, T., Toyoshima, S., Sugita, A., Ito, T., Suwabe, A., Yamahata, K., ... Okada, K. (2006). In vitro susceptibilites to levofloxacin and various antibacterial agents of 18,639 clinical isolates obtained from 77 centers in 2004. Japanese Journal of Antibiotics, 59(6), 428-451.