In vitro evaluation of osteoblast response to sol-gel derived gelatin-siloxane hybrids

Lei Ren, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cytotoxicity and cytocompatibility of porous gelatin-siloxane hybrids were evaluated due to osteoblastic cell (MC3T3-E1) proliferation, ALP activity, or their responses to the hybrids and their extracts. The hybrids were found intoxic, and appropriate incorporation of calcium ions stimulated proliferation and differentiation in vitro. Cells were seeded into the porous hybrids and the cell morphology was studied. The hybrids involving calcium ions favored osteoblast growth and differentiation.

Original languageEnglish
Pages (from-to)1137-1140
Number of pages4
JournalJournal of Sol-Gel Science and Technology
Volume26
Issue number1-3
DOIs
Publication statusPublished - Jan 1 2003

Keywords

  • Cell culture
  • Cytocompatibility
  • Cytotoxicity
  • Gelatin
  • Hybrids
  • Siloxane

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Biomaterials
  • Condensed Matter Physics
  • Materials Chemistry

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