In vitro evaluation of calcium alginate gels as matrix for iontophoresis electrodes

Haruka Haida, Shizuka Ando, Saori Ogami, Ryo Wakita, Hikaru Kohase, Norio Saito, Tomohiko Yoshioka, Toshiyuki Ikoma, Junzo Tanaka, Masahiro Umino, Haruhisa Fukayama

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Calcium alginate gel has some unique properties, such as the capability to keep the drugs, bioadhesiveness, safety, and low cost. The purpose of this study is to determine whether calcium alginate gel can be used as a matrix of electrodes for iontophoresis (IOP). We measured the concentration of lidocaine transported from calcium alginate gels with various concentrations of alginic acid using an in vitro experimental cell with square-wave alternating current (AC) application. Temperature and pH changes were also determined during AC-IOP. The results revealed that lidocaine was released from calcium alginate gels at concentrations nearly 1.71-fold larger at 5 V, 60 min after AC application than in the case of passive diffusion. Lidocaine transport depended on the alginic acid concentration in the gels. Although there were slight increases in temperature and pH, chemical and thermal burns were not severe enough to be a concern. In conclusion, the calcium alginate gel can be used as a possible matrix for IOP electrodes.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalJournal of Medical and Dental Sciences
Issue number1
Publication statusPublished - 2012
Externally publishedYes


  • Alternating current (ac)
  • Calcium alginate gel
  • Drug delivery system (DDS)
  • Electrode
  • Iontophoresis (IOP)

ASJC Scopus subject areas

  • Dentistry(all)


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