In vitro degradation behavior of hydroxyapatite

S. Hayakawa

doi:10.1016/B978178242033000004-3

In vitro degradation behavior of hydroxyapatite

S. Hayakawa

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

This chapter discusses in vitro degradation behaviors of calcium phosphate particles, such as nano-crystalline hydroxyapatite (HAp) and ion-substituted HAp synthesized by the wet-chemical processing method, and how their microstructure affects their initial dissolution profiles and kinetics. The chapter reviews several in vitro evaluation techniques for biodegradability of calcium phosphate ceramics and several models representing dissolution profiles and kinetics. The chapter then discusses the relationship between the heterogeneous structure of nano-crystalline HAp and the initial dissolution behaviors in acidic buffer solution.

Original language	English
Title of host publication	Hydroxyapatite (HAp) for Biomedical Applications
Publisher	Elsevier Ltd
Pages	85-105
Number of pages	21
ISBN (Electronic)	9781782420415
ISBN (Print)	9781782420330
DOIs	https://doi.org/10.1016/B978178242033000004-3
Publication status	Published - Feb 27 2015

Keywords

Amorphous phase
Biodegradation
Calcium phosphate
Disordered phase
Dissolution kinetics
Dissolution rate
Hydroxyapatite
In vitro degradation
Ionic substitution
Nano-crystal

ASJC Scopus subject areas

Engineering(all)
Materials Science(all)

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10.1016/B978178242033000004-3

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abstract = "This chapter discusses in vitro degradation behaviors of calcium phosphate particles, such as nano-crystalline hydroxyapatite (HAp) and ion-substituted HAp synthesized by the wet-chemical processing method, and how their microstructure affects their initial dissolution profiles and kinetics. The chapter reviews several in vitro evaluation techniques for biodegradability of calcium phosphate ceramics and several models representing dissolution profiles and kinetics. The chapter then discusses the relationship between the heterogeneous structure of nano-crystalline HAp and the initial dissolution behaviors in acidic buffer solution.",

keywords = "Amorphous phase, Biodegradation, Calcium phosphate, Disordered phase, Dissolution kinetics, Dissolution rate, Hydroxyapatite, In vitro degradation, Ionic substitution, Nano-crystal",

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AB - This chapter discusses in vitro degradation behaviors of calcium phosphate particles, such as nano-crystalline hydroxyapatite (HAp) and ion-substituted HAp synthesized by the wet-chemical processing method, and how their microstructure affects their initial dissolution profiles and kinetics. The chapter reviews several in vitro evaluation techniques for biodegradability of calcium phosphate ceramics and several models representing dissolution profiles and kinetics. The chapter then discusses the relationship between the heterogeneous structure of nano-crystalline HAp and the initial dissolution behaviors in acidic buffer solution.

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KW - Biodegradation

KW - Calcium phosphate

KW - Disordered phase

KW - Dissolution kinetics

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KW - In vitro degradation

KW - Ionic substitution

KW - Nano-crystal

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