Abstract
This chapter discusses in vitro degradation behaviors of calcium phosphate particles, such as nano-crystalline hydroxyapatite (HAp) and ion-substituted HAp synthesized by the wet-chemical processing method, and how their microstructure affects their initial dissolution profiles and kinetics. The chapter reviews several in vitro evaluation techniques for biodegradability of calcium phosphate ceramics and several models representing dissolution profiles and kinetics. The chapter then discusses the relationship between the heterogeneous structure of nano-crystalline HAp and the initial dissolution behaviors in acidic buffer solution.
| Original language | English |
|---|---|
| Title of host publication | Hydroxyapatite (HAp) for Biomedical Applications |
| Publisher | Elsevier Ltd |
| Pages | 85-105 |
| Number of pages | 21 |
| ISBN (Electronic) | 9781782420415 |
| ISBN (Print) | 9781782420330 |
| DOIs | |
| Publication status | Published - Feb 27 2015 |
Keywords
- Amorphous phase
- Biodegradation
- Calcium phosphate
- Disordered phase
- Dissolution kinetics
- Dissolution rate
- Hydroxyapatite
- In vitro degradation
- Ionic substitution
- Nano-crystal
ASJC Scopus subject areas
- Engineering(all)
- Materials Science(all)
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Cite this
Hayakawa, S. (2015). In vitro degradation behavior of hydroxyapatite. In Hydroxyapatite (HAp) for Biomedical Applications (pp. 85-105). Elsevier Ltd. https://doi.org/10.1016/B978178242033000004-3