Abstract
Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.
| Original language | English |
|---|---|
| Title of host publication | 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 |
| Publisher | IEEE Computer Society |
| ISBN (Print) | 9781479915293 |
| DOIs | |
| Publication status | Published - 2013 |
| Event | 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan Duration: Nov 10 2013 → Nov 13 2013 |
Other
| Other | 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 |
|---|---|
| Country | Japan |
| City | Nagoya |
| Period | 11/10/13 → 11/13/13 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
Cite this
In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. / Shirosaki, Yuki; Okamoto, Kohei; Hayakawa, Satoshi; Osaka, Akiyoshi.
2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013. IEEE Computer Society, 2013. 6710442.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids
AU - Shirosaki, Yuki
AU - Okamoto, Kohei
AU - Hayakawa, Satoshi
AU - Osaka, Akiyoshi
PY - 2013
Y1 - 2013
N2 - Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.
AB - Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.
UR - http://www.scopus.com/inward/record.url?scp=84893723545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893723545&partnerID=8YFLogxK
U2 - 10.1109/MHS.2013.6710442
DO - 10.1109/MHS.2013.6710442
M3 - Conference contribution
AN - SCOPUS:84893723545
SN - 9781479915293
BT - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
PB - IEEE Computer Society
ER -