In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids

Yuki Shirosaki; Kohei Okamoto; Satoshi Hayakawa; Akiyoshi Osaka

doi:10.1109/MHS.2013.6710442

In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids

Yuki Shirosaki, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.

Original language	English
Title of host publication	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
Publisher	IEEE Computer Society
ISBN (Print)	9781479915293
DOIs	https://doi.org/10.1109/MHS.2013.6710442
Publication status	Published - 2013
Event	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan Duration: Nov 10 2013 → Nov 13 2013

Other

Other	2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
Country	Japan
City	Nagoya
Period	11/10/13 → 11/13/13

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ASJC Scopus subject areas

Electrical and Electronic Engineering

Cite this

Shirosaki, Y., Okamoto, K., Hayakawa, S., & Osaka, A. (2013). In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 [6710442] IEEE Computer Society. https://doi.org/10.1109/MHS.2013.6710442

Shirosaki, Y, Okamoto, K, Hayakawa, S & Osaka, A 2013, In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. in 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013., 6710442, IEEE Computer Society, 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013, Nagoya, Japan, 11/10/13. https://doi.org/10.1109/MHS.2013.6710442

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Access to Document

10.1109/MHS.2013.6710442