In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids

Yuki Shirosaki, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.

Original languageEnglish
Title of host publication2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
PublisherIEEE Computer Society
ISBN (Print)9781479915293
DOIs
Publication statusPublished - 2013
Event2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan
Duration: Nov 10 2013Nov 13 2013

Other

Other2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
CountryJapan
CityNagoya
Period11/10/1311/13/13

Fingerprint

Biodegradability
Microspheres
Chitosan
Silicates
Biocompatibility
Polymers
Polymer matrix
Microfluidics
Neurons

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Shirosaki, Y., Okamoto, K., Hayakawa, S., & Osaka, A. (2013). In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 [6710442] IEEE Computer Society. https://doi.org/10.1109/MHS.2013.6710442

In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. / Shirosaki, Yuki; Okamoto, Kohei; Hayakawa, Satoshi; Osaka, Akiyoshi.

2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013. IEEE Computer Society, 2013. 6710442.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shirosaki, Y, Okamoto, K, Hayakawa, S & Osaka, A 2013, In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. in 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013., 6710442, IEEE Computer Society, 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013, Nagoya, Japan, 11/10/13. https://doi.org/10.1109/MHS.2013.6710442
Shirosaki Y, Okamoto K, Hayakawa S, Osaka A. In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013. IEEE Computer Society. 2013. 6710442 https://doi.org/10.1109/MHS.2013.6710442
Shirosaki, Yuki ; Okamoto, Kohei ; Hayakawa, Satoshi ; Osaka, Akiyoshi. / In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013. IEEE Computer Society, 2013.
@inproceedings{fba7ef9827da4e28820a42c7b0632980,
title = "In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids",
abstract = "Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.",
author = "Yuki Shirosaki and Kohei Okamoto and Satoshi Hayakawa and Akiyoshi Osaka",
year = "2013",
doi = "10.1109/MHS.2013.6710442",
language = "English",
isbn = "9781479915293",
booktitle = "2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013",
publisher = "IEEE Computer Society",
address = "United States",

}

TY - GEN

T1 - In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids

AU - Shirosaki, Yuki

AU - Okamoto, Kohei

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

PY - 2013

Y1 - 2013

N2 - Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.

AB - Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.

UR - http://www.scopus.com/inward/record.url?scp=84893723545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893723545&partnerID=8YFLogxK

U2 - 10.1109/MHS.2013.6710442

DO - 10.1109/MHS.2013.6710442

M3 - Conference contribution

AN - SCOPUS:84893723545

SN - 9781479915293

BT - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013

PB - IEEE Computer Society

ER -