In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids

Yuki Shirosaki, Kohei Okamoto, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.

Original languageEnglish
Title of host publication2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
PublisherIEEE Computer Society
ISBN (Print)9781479915293
DOIs
Publication statusPublished - Jan 1 2013
Event2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 - Nagoya, Japan
Duration: Nov 10 2013Nov 13 2013

Publication series

Name2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013

Other

Other2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
CountryJapan
CityNagoya
Period11/10/1311/13/13

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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    Shirosaki, Y., Okamoto, K., Hayakawa, S., & Osaka, A. (2013). In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids. In 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013 [6710442] (2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013). IEEE Computer Society. https://doi.org/10.1109/MHS.2013.6710442