TY - GEN
T1 - In vitro cytocompatibility of microspheres derived from chitosan-silicate hybrids
AU - Shirosaki, Yuki
AU - Okamoto, Kohei
AU - Hayakawa, Satoshi
AU - Osaka, Akiyoshi
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.
AB - Microsphere-based therapy is used to allow drug release to treat the critical site through the choice and formulation of variations drug-polymer combinations. They are also used to control the release of insoluble drug by the biodegradability of polymer. Chitosan is one of the candidates for the polymer matrix because their biodegradability and biocompatibility. Recently, we prepared and characterized the inorganic-organic hybrid derived from chitosan and siloxane units. This hybrid showed the excellent biocompatibility for the osteoblastic cells, fibroblastic cells, and nerve cells, etc. In this study, the microspheres were prepared from this hybrid using the microfluidic systems. The biodegradability, drug releasing behavior and cytocompatibility were investigated.
UR - http://www.scopus.com/inward/record.url?scp=84893723545&partnerID=8YFLogxK
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U2 - 10.1109/MHS.2013.6710442
DO - 10.1109/MHS.2013.6710442
M3 - Conference contribution
AN - SCOPUS:84893723545
SN - 9781479915293
T3 - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
BT - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
PB - IEEE Computer Society
T2 - 2013 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2013
Y2 - 10 November 2013 through 13 November 2013
ER -