Abstract
Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
Original language | English |
---|---|
Pages (from-to) | 249-252 |
Number of pages | 4 |
Journal | Journal of Ethnopharmacology |
Volume | 86 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - Jun 2003 |
Keywords
- Antimalaria
- Antiplasmodial
- FCR-3
- Plasmodium falciparum
- Vietnamese medicinal plants
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery