Abstract
Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
| Original language | English |
|---|---|
| Pages (from-to) | 249-252 |
| Number of pages | 4 |
| Journal | Journal of Ethnopharmacology |
| Volume | 86 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Jun 2003 |
Fingerprint
Keywords
- Antimalaria
- Antiplasmodial
- FCR-3
- Plasmodium falciparum
- Vietnamese medicinal plants
ASJC Scopus subject areas
- Pharmacology
Cite this
In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. / Tran, Quan Le; Tezuka, Yasuhiro; Ueda, Jun Ya; Nguyen, Nhan Trung; Maruyama, Yukiko; Begum, Khurshida; Kim, Hye-Sook; Wataya, Yusuke; Tran, Qui Kim; Kadota, Shigetoshi.
In: Journal of Ethnopharmacology, Vol. 86, No. 2-3, 06.2003, p. 249-252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine
AU - Tran, Quan Le
AU - Tezuka, Yasuhiro
AU - Ueda, Jun Ya
AU - Nguyen, Nhan Trung
AU - Maruyama, Yukiko
AU - Begum, Khurshida
AU - Kim, Hye-Sook
AU - Wataya, Yusuke
AU - Tran, Qui Kim
AU - Kadota, Shigetoshi
PY - 2003/6
Y1 - 2003/6
N2 - Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
AB - Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.
KW - Antimalaria
KW - Antiplasmodial
KW - FCR-3
KW - Plasmodium falciparum
KW - Vietnamese medicinal plants
UR - http://www.scopus.com/inward/record.url?scp=0038640087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038640087&partnerID=8YFLogxK
U2 - 10.1016/S0378-8741(03)00045-X
DO - 10.1016/S0378-8741(03)00045-X
M3 - Article
C2 - 12738095
AN - SCOPUS:0038640087
VL - 86
SP - 249
EP - 252
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
SN - 0378-8741
IS - 2-3
ER -