In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Quan Le Tran, Yasuhiro Tezuka, Jun Ya Ueda, Nhan Trung Nguyen, Yukiko Maruyama, Khurshida Begum, Hye Sook Kim, Yusuke Wataya, Qui Kim Tran, Shigetoshi Kadota

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalJournal of Ethnopharmacology
Volume86
Issue number2-3
DOIs
Publication statusPublished - Jun 2003

Keywords

  • Antimalaria
  • Antiplasmodial
  • FCR-3
  • Plasmodium falciparum
  • Vietnamese medicinal plants

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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