In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Quan Le Tran; Yasuhiro Tezuka; Jun Ya Ueda; Nhan Trung Nguyen; Yukiko Maruyama; Khurshida Begum; Hye Sook Kim; Yusuke Wataya; Qui Kim Tran; Shigetoshi Kadota

doi:10.1016/S0378-8741(03)00045-X

In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine

Quan Le Tran, Yasuhiro Tezuka, Jun Ya Ueda, Nhan Trung Nguyen, Yukiko Maruyama, Khurshida Begum, Hye Sook Kim, Yusuke Wataya, Qui Kim Tran, Shigetoshi Kadota

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC₅₀ values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC₅₀ value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.

Original language	English
Pages (from-to)	249-252
Number of pages	4
Journal	Journal of Ethnopharmacology
Volume	86
Issue number	2-3
DOIs	https://doi.org/10.1016/S0378-8741(03)00045-X
Publication status	Published - Jun 2003

Keywords

Antimalaria
Antiplasmodial
FCR-3
Plasmodium falciparum
Vietnamese medicinal plants

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. / Tran, Quan Le; Tezuka, Yasuhiro; Ueda, Jun Ya; Nguyen, Nhan Trung; Maruyama, Yukiko; Begum, Khurshida; Kim, Hye Sook; Wataya, Yusuke; Tran, Qui Kim; Kadota, Shigetoshi.

In: Journal of Ethnopharmacology, Vol. 86, No. 2-3, 06.2003, p. 249-252.

Research output: Contribution to journal › Article › peer-review

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abstract = "Among 42 extracts, prepared from 14 medicinal plants used in Vietnamese traditional medicine to treat malaria, 24 were found to have antiplasmodial activity by inhibiting the growth of the chloroquine-resistant Plasmodium falciparum strain FCR-3 with EC50 values less than 10μg/ml. Each medicinal plant possessed at least one active extract. The methanol extract of Coscinium fenestratum had the strongest antiplasmodial activity with EC50 value of 0.5μg/ml. Activity-guided fractionation led to identification of berberine as the major active constituent.",

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AU - Begum, Khurshida

AU - Kim, Hye Sook

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